细胞内氧化应激荧光探针的特征：显微镜-猫眼课题宝

细胞内氧化应激荧光探针的特征：显微镜

批准号：

6349420

负责人：

L STIRLING CHURCHMAN

金额：

$3.66万

依托单位：

CORNELL UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2000

资助国家：

美国

项目状态：

已结题

起止时间：

2000-09-01 至 2001-08-31

来源：

https://reporter.nih.gov/project-details/6349420

关键词：

animal tissue bioengineering /biomedical engineering biomedical equipment development biomedical resource human tissue immunology inflammation lasers lymphatic system technology /technique

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英文摘要

Paraneurons (parafollicular cells), found in the thyroid gland, are endocrine cells, but developmentally related to neurons and moreover can be readily isolated in a pure form for experimental analysis. Serotoninergic neurons cannot similarly be isolated. Work on this cell preparation has revealed that the secretion competent granule interiors experience transient pH drops after cell stimulation. Chloride channels that are regulated by protein kinases C and G are implicated. We are simultaneously imaging 5-HT and a granule pH marker to investigate proposed correlations between 5-HT release and granule pH.

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