Core--Molecular biology

核心--分子生物学

• 批准号: 6326025
• 负责人: ALLAN J TOBIN
• 金额: $ 14.5万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6326025
• 关键词: GABA aminotransferase; biomedical facility; genetic mapping; subthalamus; tissue /cell culture

The Molecular Biology Core will be responsible for the production and in vitro characterization and maintenance o GABA-producing cells that will be used in all three projects of the Center. In addition, the core will develop and use DNA microarray technology to identify candidate genes that are altered in the subthalamic nucleus and its target areas in the animal models of Parkinson's disease used in the Center.

分子生物学核心将负责gaba产生细胞的生产、体外表征和维护，这些细胞将用于该中心的所有三个项目。此外，该中心将开发和使用DNA微阵列技术，在该中心使用的帕金森病动物模型中，识别在丘脑底核及其靶区发生改变的候选基因。