MOLEC BIOL INFRASTRUCTURE: GENETICS & IMMUNOL CHEM: GENETIC DIS IN HISPANICS

自从庞塞学院的RCMI项目实施以来， 1985年，在医学方面取得了重大进展， 研究基础设施，以支持三大核心研究 研究领域：环境毒理学、免疫化学和艾滋病研究。 事实上，RCMI计划实际上是主要的推动力， 负责将我们的机构从一个 以教学为导向的学校，以充满活力的研究中心。 为了评估目前的研究活动，向前，到下一个 竞争力水平，我们必须发展和加强 支持现代分子生物学研究的基础设施。 因此，我们的研究设施已经达到了一个阶段， 需要使用设施和设备的研究活动 开展现代蛋白质化学和核酸方面的工作 技术. 在本申请中，我们请求支持建立 庞塞医学院的分子生物学项目。 是 目的是，作为分子的主要活动之一， 生物程序，一个集中的多用户设施，包含基本的 以及最先进的核酸和蛋白质研究设备 将被创建。 拟议分子的长期目标 庞塞医学院的生物学课程是提供 必要的设施，并促进研究环境， 卓越，激励我们的设施，使重大的科学 对生物医学科学的贡献。 长期目标将是 具体目标如下：（1）发展和 加强庞塞医学院必要的基础设施， 通过购买关键基础和最先进的设备， 改善现有的物质设施，以便 研究人员进行现代分子生物学研究，（2） 通过讲习班、实验室 为调查人员举办的示范和特别研讨会， 将分子生物学技术纳入其现有研究 （3）协助机构招聘 在病毒学，免疫遗传学， 诊断遗传性疾病，细菌和人类 （4）建立必要的设施， 主要遗传疾病的分子诊断研究， 影响少数民族社区;（5）为当地居民提供服务 寡核苷酸和肽的研究人员 合成，DNA测序，N-末端氨基酸序列分析， 和大分子的纯化。

Since the implementation or the RCMI Program at Ponce School of Medicine, in 1985, significant progress has been achieved in enhancing the research infrastructure to support studies in three major core areas: Environmental toxicology, immuno- chemistry and AIDS Research. Indeed, the RCMI Program has been virtually the main driving force responsible for the transformation of our institution from a practically teaching oriented School to a vigorous Research Center. In order to evaluate current research activities, forward, to the next level of competitiveness, we must develop and strengthen an infrastructure that supports research in modern Molecular Biology. Thus, our research facility has already reached a stage in their research initiatives that require the use of facilities and equipment to carry out work in modern Protein Chemistry and Nucleic Acids technology. In the present application we request support for the establishment of a Molecular Biology Program at Ponce School of Medicine. It is intended that, as part of one of the major activities of the Molecular Biology Program, a centralized multiuser facility, containing basic and state-of-the-art equipment for nucleic acids and protein research will be created. The long term goals of the proposed Molecular Biology Program at Ponce School of Medicine is to provide the necessary facilities, and to foster a research environment of excellence that stimulates our facility to make significant scientific contributions to the biomedical sciences. The long term goals will be approached through the following specific aims: (1) to develop and strengthen the necessary infrastructure at Ponce School of Medicine, through the acquisition of key basis and state-of-the-art equipment by improving the existing physical facilities, in order to enable investigators to conduct research in modern molecular biology, (2) to provide training and advise, through workshops, laboratory demonstrations and special seminars to investigators that need to incorporate molecular biology techniques to their ow research initiatives, (3) to assist the institution in the recruitment of competent research facility in areas such as virology, immunogenetics, diagnosis of genetically inherited diseases, bacterial and human genetics, (4) to establish the necessary facilities to conduct research in the molecular diagnosis of major genetic diseases that effect the minority community and (5) to provide service to local researchers in the elaboration of oligonucleotide and peptide synthesis, DNA sequencing, N-terminal Amino acid sequence analysis, and purification of macromolecules.