Pilot--Protective mechanisms of genistein against breast cancer

试点--金雀花素对乳腺癌的保护机制

• 批准号: 6359984
• 负责人: HEIDE SCHATTEN
• 金额: $ 6.54万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359984
• 关键词: alternative medicine; breast neoplasms; cell cycle; cell proliferation; centromere; free radicals; genistein; mitochondria; neoplastic growth; oxidative stress; pharmacokinetics; phosphorylation

DESCRIPTION: This project will test whether genistein's anti- proliferative effects occur through inhibition of abnormal phosphorylation of S-phase centromere proteins and nuclear mitotic apparatus protein NuMA or through reductions in free radical damage to mitochondria.

产品说明：该项目将测试染料木黄酮的抗增殖作用是否通过抑制S期着丝粒蛋白和核有丝分裂器蛋白NuMA的异常磷酸化或通过减少线粒体的自由基损伤而发生。