Neural Mechanisms of Pair Bonding

配对的神经机制

• 批准号: 6528998
• 负责人: Miranda M Lim
• 金额: $ 2.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-06 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6528998
• 关键词: GABA receptor; antibody; behavioral /social science research tag; behavioral genetics; dopamine receptor; dopamine transporter; gene expression; glutamate receptor; hormone receptor; lenticular nucleus; neuroanatomy; neurobiology; neurochemistry; neurons; neuropeptide receptor; neuropeptides; neuropsychology; neurotransmitters; phenotype; preference; protooncogene; sex behavior; sex partner; substance P; vasopressins; vole

DESCRIPTION (provided by applicant): My research proposal focuses on a fundamental question in behavioral neuroscience: What is the neural basis of social attachment? In our model of social attachment using the monogamous prairie vole, we have identified a brain region, the ventral pallidum, and a neuropeptide receptor, the vasopressin receptor (V1aR), that appear to be critical for the formation of the pair bond between monogamous mates. The three specific aims outlined in this proposal will further elucidate the role of the VIaR in the ventral pallidum during pair bond formation. First, we will examine the neuronal activation, assessed by induction of c-Fos expression, in the ventral pallidum and other candidate brain regions during mating. Next, we will determine the necessity of VIaR in the ventral pallidum or other candidate regions in pair bond formation using pharmacological manipulation. Finally, we will identify the other neurotransmitter and neuropeptide systems that colocalize with V1aR in these critical regions and which of these may be involved during pair bond formation. The results from these aims will help us understand how the V1aR may be acting to mediate pair bonding and ultimately generate novel and viable hypotheses regarding the neurobiology of social attachment.

描述（由申请人提供）：我的研究计划侧重于 行为神经科学的基本问题：行为的神经基础是什么？ 社会依恋？在我们使用一夫一妻制的社会依恋模型中 草原田鼠，我们已经确定了一个大脑区域：腹侧苍白球和 神经肽受体，加压素受体（V1aR），似乎是 对于一夫一妻制伴侣之间配偶关系的形成至关重要。三个 该提案中概述的具体目标将进一步阐明 VIaR 在成对键形成过程中位于腹侧苍白球。首先，我们将检查 通过诱导 c-Fos 表达来评估神经元激活 交配期间的腹侧苍白球和其他候选大脑区域。接下来，我们将 确定腹侧苍白球或其他候选者中 VIaR 的必要性 使用药理操作形成配对键的区域。最后，我们 将识别其他神经递质和神经肽系统 在这些关键区域中与 V1aR 共定位，其中哪些可能是 参与配对键形成过程。这些目标的结果将帮助我们 了解 V1aR 如何发挥作用来介导配对结合，并最终 产生关于社会神经生物学的新颖且可行的假设 依恋。