RENOV OF CHEMISTRY BLDG: PROTEIN STRUCT, SENSOR TECH, ANTHRAX, ION TRANSPORT

描述（由申请人提供）：化学大楼的翻新以增加现代研究设施的数量对阿肯色大学生物医学研究的未来至关重要。面积超过13000平方米。在此申请的资金支持下，将有1 / 3的生物医学研究空间用于教师研究小组和共享仪器实验室。长期目标是扩大和改善生物医学研究的可用空间，并允许这种研究的持续增长。具体目标：1)整个建筑以及本申请中讨论的特定生物医学研究空间将达到符合所有现行规范和法规的标准。所有的机械和电气系统将完全更换，大部分内部空间将重新安排，以最好地满足研究需求；2)实验室将进行翻新，以容纳博士的研究小组。弗朗西斯·米勒、比尔·达勒姆、马特·麦金托什、肯尼斯·特恩布尔和钦宇，以及一名新聘用的教员；3)提供蛋白质x射线晶体实验室、蛋白质核磁共振实验室、蛋白质结构溶液与可视化计算机实验室、质谱实验室共用仪器空间；4)扩大和改进后的空间将用于扩展现有的核酸化学、药物合成和电子传递基团。它将用于建立一个新的蛋白质核磁共振基团和一个组合药物发现研究组。共享的仪器实验室将用于研究和阐明控制蛋白质结构和功能的基本原理。腾出的空间将用于扩大其他团体的生物医学研究工作。

DESCRIPTION (provided by applicant): Renovation of the Chemistry Building to increase the amount of modern research facilities is critical for the future of biomedical research at the University of Arkansas. The over 13,000 sq. ft. of biomedical research space renovated by the funding requested here will be used for faculty research groups as well as for shared instrumentation laboratories. The long-term goal is to expand and improve the space available for biomedical research and allow continued growth of such research. Specific Aims: 1) The building overall as well as the specific biomedical research spaces discussed in this application will be brought up to a standard meeting all current codes and regulations. All mechanical and electrical systems will be completely replaced and most interior spaces rearranged to best meet research needs; 2) Laboratories will be renovated to house the research groups of Drs. Francis Millett, Bill Durham, Matt McIntosh, Kenneth Turnbull, and Chin Yu as well as one new faculty member to be hired; 3) Shared instrumentation space will be provided for Protein X-ray Crystallography Laboratory, Protein Nuclear Magnetic Resonance (NMR) Laboratories, Protein Structure Solution and Visualization Computer Laboratory, and Mass Spectrometry Laboratories; and 4) This expanded and improved space will be used to expand existing nucleic acid chemistry, drug synthesis, and electron transport groups. It will be used to establish a new protein NMR group and a combinatorial drug discovery research group. The shared instrumentation laboratories will be used for the study and elucidation of the fundamental principles that govern the structure and function of proteins. Vacated space will be used to expand biomedical research efforts of other groups.