IMPROVE OF MEMBRANE BIOL FACIL: CF

描述(由申请人提供)：UCD，SOM寻求联邦援助，以翻新基础生物医学研究设施，以支持在膜生物学领域的新倡议的发展。这项改进将把一个由8名常设调查员组成的干部队伍和5个正在积极征聘的新职位中的最初3个合并在升级和重新配置的空间内。该项目促进了一个广泛的战略，以提高研究活动的规模和地位，并加强基础和临床研究人员之间的联系。方法是确定现有科学实力的领域，并有主题地招募更多有才华的调查人员，特别是初级调查人员。选择膜生物学的增强建立在广泛的机构规划的基础上，由杰出的学术领袖组成的外部小组进行验证，并随后对教职员工提交的竞争性项目提案进行审查。该项目解决了为膜生物学提供适当的发射空间方面的多个问题。也就是说，它将：1)弥补现有已有24年历史的实验室群中的一些实际缺陷；2)用更大的共享实验室和支持空间来补充个别实验室，以加强合作和灵活性，以满足未来的需求；以及3)通过更有效的设计和一些以前的非研究空间的转换，帮助缓解研究空间的短缺。该项目涉及9472个可分配面积的大范围翻新。英国《金融时报》(11,144平方英尺FT.)。有279.4万美元可以作为机构匹配，但没有足够的资金独立进行所有必要的改进，预算为479.4万美元。将从该项目中受益的项目将在六年内获得150万美元的额外机构支持，用于五名新教师的启动资金，以及用于额外的共享和核心设备的15万美元。该校还竞争性地每年奖励200万美元的校内飞行员奖励，以及每年60万至200万美元的共享设备资金。预计膜生物学计划也将受益于这些正在进行的资金来源，以满足未来的发展需求。本申请是国家研究资源中心(NCRR)资助的C06项目的后续项目，该项目于2000年12月完成。该项目解决了本申请中的学科实验室所在大楼的其他实验室和基本基础设施缺陷问题。

DESCRIPTION (provided by applicant): The UCD, SOM seeks federal assistance to renovate basic biomedical research facilities to support development of a new initiative in Membrane Biology. The improvement would co-locate, in upgraded and reconfigured space, a cadre of eight established investigators and the initial three of five new positions under active recruitment. The project facilitates a broad strategy to enhance the size and stature of research activities and strengthen links between basic and clinical investigators. The approach has been to identify areas of existing scientific strength and thematically recruit additional talented investigators, particularly at the junior level. The selection of Membrane Biology for enhancement builds on extensive institutional planning, validated by an external panel of distinguished academic leaders, and a subsequent review of competitive program proposals submitted by the faculty. The project addresses multiple problems in providing appropriate launch space for Membrane Biology. Namely, it would: 1) remedy a number of physical deficiencies in a cluster of existing 24-year-old laboratories; 2) supplement individual laboratories with larger shared laboratories and support space to enhance collaboration and flexibility for meeting future needs; and 3) help alleviate a shortage of research space through more efficient design and the conversion of some former non-research space. The project involves extensive renovations of 9,472 assignable sq. ft. (11,144 sq. ft.). There is $2.794 million available as an institutional match, but insufficient funds to independently undertake all of the necessary improvements, which are budgeted at $4.794 million. The program that will benefit from this project will receive additional institutional support of $1.5 million over six years in start-up funds for five new faculty recruits, plus $150,000 for additional shared and core equipment. The school also competitively awards $2 million per year in intramural pilot awards and another $600,000 - $2 million per year in shared equipment funds. It is anticipated that the Membrane Biology program will also benefit from these ongoing funded sources to meet future development needs. This application follows-up on a previous National Center for Research Resources (NCRR)-funded C06 project, that was completed in December 2000. That project addressed other laboratory and basic infrastructure deficiencies in the same building that contains the subject laboratories in the current application.