HEALTH BURDEN OF CO INFECTING DEER ASSOCIATED ZOONOTIC CNS DISEASE

一系列螺旋体、原生动物、病毒和立克次体病原体同时感染美国东部鹿群丰富地区的居民。鹿和依赖这种宿主的病媒节肢动物的丰度最近有所增加。这些与鹿有关的病原体中有几种会引起神经系统疾病。本研究的目的是：(1)确定美国东北部居民中由鹿相关病原体引起脑膜炎和脑炎的频率，以及这些病原体合并发生的频率；(2)评估这些鹿相关病原体对人类健康造成的负担，并确定糖果是否与致病机制协同作用。我们将研究由这些病原体引起的脑膜炎或脑炎后的结果，以及与仅存在一种这样的病原体相比，合并感染者是否会经历更严重的急性疾病或更大的神经系统后遗症。

An array of spirochetal, protozoan, viral and rickettsial pathogens concurrently infect residents of sites in eastern US in which deer are abundant. The abundance of deer and that of the vector arthropods that depend on this host recently have increased. Several of these deer-associated pathogens cause neurologic disease. The objectives of this study are to (1) determine how frequency meningitis and encephalitis are caused by deer-associated pathogens in residents of the northeastern US and how frequently these pathogens occur in combination; (2) Estimate the burden on human health imposed by these deer-associated pathogen and determine whether confection synergizes pathogenesis. We will look at the outcome following meningitis or encephalitis caused by these pathogens, and whether coinfected people experience a greater severity of acute illness or greater neurologic sequelae than if only one such pathogen were present.