课题基金 / 基金详情

EFFECT OF TRYPTOPHAN DEPLETION ON MOOD AND CRAVING IN PATIENTS WITH DEPRESSION

EFFECT OF TRYPTOPHAN DEPLETION ON MOOD AND CRAVING IN PATIENTS WITH DEPRESSION
色氨酸消耗对抑郁症患者情绪和渴望的影响
批准号：
6309856
负责人：
HENRY RICHARD KRANZLER
金额：
$1.91万
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6309856
关键词：
alcoholic beverage consumption alcoholism /alcohol abuse aminoacid metabolism antidepressants clinical research craving emotions human subject human therapy evaluation neurotransmitter metabolism placebos serotonin sertraline tryptophan

项目摘要

项目成果

HENRY RICHARD KRANZLER的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Although major depression and alcohol dependence co-occur commonly, the pathophysiologic basis for this comorbidity is poorly understood. This study examines the role of serotonin (5-HT) in producing depressive symptoms in alcoholics. A total of 40 depressed alcoholics in remission from both disorders will undergo two laboratory sessions in random order. During these sessions they will ingest an amino acid mixture containing all amino acids on one day, and all amino acids with the exception of tryptophan (TRP) on a second occasion one week later. Due to the stimulation of protein synthesis, TRP, the precursor of 5-HT, is depleted when the amino acid load containing no TRP is administered. It is hypothesized that depressed alcoholics will show a transient increase in depressive symptoms due to TRP depletion.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Penn PET Addiction Center of Excellence (Penn PACE)
  • 批准号：
    9794253
  • 项目类别：
  • 资助金额：
    $176.27万
  • 财政年份：
    2019
  • 负责人：
    HENRY RICHARD KRANZLER
  • 依托单位：
    UNIVERSITY OF PENNSYLVANIA
Clinical Core
  • 批准号：
    10201545
  • 项目类别：
  • 资助金额：
    $36.93万
  • 财政年份：
    2019
  • 负责人：
    HENRY RICHARD KRANZLER
  • 依托单位：
    UNIVERSITY OF PENNSYLVANIA
Penn PET Addiction Center of Excellence (PACE)
  • 批准号：
    10713668
  • 项目类别：
  • 资助金额：
    $40.6万
  • 财政年份：
    2019
  • 负责人：
    HENRY RICHARD KRANZLER
  • 依托单位：
    UNIVERSITY OF PENNSYLVANIA
Penn PET Addiction Center of Excellence (Penn PACE)
  • 批准号：
    10201543
  • 项目类别：
  • 资助金额：
    $184.63万
  • 财政年份：
    2019
  • 负责人：
    HENRY RICHARD KRANZLER
  • 依托单位：
    UNIVERSITY OF PENNSYLVANIA