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EFFECT OF LOW MOLECULAR WEIGHT HEPARIN ON SICKLE CELL

EFFECT OF LOW MOLECULAR WEIGHT HEPARIN ON SICKLE CELL
低分子肝素对镰状细胞的影响
批准号：
6308599
负责人：
LORI A STYLES
金额：
$1.75万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6308599
关键词：
anticoagulants blood disorder chemotherapy child (0-11) clinical research drug screening /evaluation heparin human subject human therapy evaluation sickle cell anemia

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中文摘要
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英文摘要
Sickle cell disease is a common B hemoglobinopathy which results in substantial morbidity and mortality. SCD is characterized by a procoagulant state which likely results from the interaction of sickled red blood cells (SRBC) with the endothelium. Hemostatic abnormalities in SCD include an increase in procoagulant factors via an increase in tissue factor (TF) production as well as a decrease in anticoagulant factors in the protein C pathway. The result of this imbalance is a well characterized increase in thrombin formation. Low molecular weight heparin (LMWH) is a simple, effective and safe means of anticoagulant therapy which could be used to treat SCD manifestations but has never been evaluated in sickle cell disease (SCD).
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