SEROLOGIC & T CELL RESPONSES TO ANTIGENS OF MYCOBACTERIUM TUBERCULOSI

血清学

• 批准号: 6308602
• 负责人: ANN LOEFFLER
• 金额: $ 1.75万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308602
• 关键词: Mycobacterium tuberculosis; bacterial antigens; child (0-11); clinical research; diagnosis design /evaluation; diagnostic tests; human subject; latent bacterial disease; tuberculin test; tuberculosis

The Mantoux test (PPD) is the gold standard for diagnosis of infection with M. tuberculosis. While the test is neither sensitive nor specific, previous efforts at a better diagnostic test have been disappointing. In children, the distinction between asymptomatic infection and active disease with M. tuberculosis is also challenging. Several new antigens of M. tuberculosis have been identified and manufactured. We will study the antibody and T-cell responses to these antigens in children with no infection, asymptomatic infection or active disease with M. tuberculosis. We hope that one or more of the new antigens will be useful in developing a sensitive and specific assay for infection or disease with M. tuberculosis.

曼图试验(PPD)是诊断结核分枝杆菌感染的金标准。虽然这项测试既不敏感也不具体，但之前为更好的诊断测试所做的努力一直令人失望。在儿童中，结核分枝杆菌无症状感染和活动性疾病之间的区别也具有挑战性。已经鉴定并生产了几种新的结核分枝杆菌抗原。我们将研究无感染、无症状感染或活动性结核杆菌感染的儿童对这些抗原的抗体和T细胞反应。我们希望一个或多个新的抗原将有助于开发一种敏感和特异的检测结核分枝杆菌感染或疾病的方法。