EPIDEMIOLOGY OF CAROTID ARTERY ATHEROSCLEROSIS IN YOUTH

青年颈动脉粥样硬化的流行病学

• 批准号: 6389502
• 负责人: PATRICIA Helen DAVIS
• 金额: $ 53.49万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6389502
• 关键词: acute phase protein; adolescence (12-20); adult human (21+); angiocardioultrasonography; atherosclerosis; blood chemistry; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; carotid artery; clinical research; computed axial tomography; disease /disorder onset; disease /disorder proneness /risk; early diagnosis; family genetics; human subject; longitudinal human study; young adult human (21-34)

DESCRIPTION: (Adapted from Investigator's Abstract) The atherosclerotic process begins in childhood and progresses through adult life resulting in coronary heart disease (CHD), stroke, and peripheral vascular disease. There is a need to identify young people at risk for premature atherosclerosis so that preventive measures can be instituted before occlusive vascular disease occurs. The ultrasonic measurement of carotid intimal-medial thickness (IMT) allows detection of early atherosclerosis and is related to incident CHD and stroke in older adults. In 1970, a population of school age children and adolescents was first examined in Muscatine, Iowa. A sample of 776 members of this longitudinal cohort, who are representative of the initial childhood population, is now aged 37 to 45 years. Their risk factors were measured in childhood, young adulthood and twice in later adult life, and they have undergone measurement of carotid IMT as well as electron beam computed tomography to identify coronary artery calcification (CAC). In this cohort, carotid IMT is significantly associated with CAC as well as current LDL cholesterol and systolic blood pressure, but only 14 percent of carotid IMT variability can be explained by these risk factors. Parents of the cohort have been assessed for cardiovascular morbidity and mortality. In this application the investigators propose to do the following: (1) examine the third generation to determine whether the offspring of cohort members with premature atherosclerosis and/or a familial history of cardiovascular disease have increased carotid IMT or elevated risk factors; (2) identify risk factors for progression of carotid IMT over four years in this cohort; and (3) measure putative risk factors for increased IMT (serologic evidence of Clamydia pneumoniae or cytomegalovirus infection, high sensitivity C-reactive protein, fibrinogen, plasminogen activator inhibitor-1 and glycosylated hemoglobin). The investigators state that the study has the potential of providing information which would allow identification of subjects at risk for atherosclerosis at an early age and may lead the way to interventions to halt or slow progression of atherosclerosis prior to the development of clinical disease.

描述：（改编自研究者摘要）动脉粥样硬化过程 从童年开始并在成年后发展，导致冠心病 心脏病（CHD）、中风和周围血管疾病。有需要 识别有过早动脉粥样硬化风险的年轻人，以便 可以在闭塞性血管疾病发生之前采取预防措施。 颈动脉内膜中层厚度 (IMT) 的超声波测量允许 检测早期动脉粥样硬化，并与冠心病和中风的发生有关 老年人。 1970 年，学龄儿童和青少年人口为 首次在爱荷华州马斯卡廷进行检查。该纵向的 776 名成员的样本 代表最初童年人口的队列现在已步入老年 37至45岁。他们的危险因素在儿童期和成年早期进行了测量 并在成年后接受两次颈动脉测量 IMT 以及电子束计算机断层扫描来识别冠状动脉 钙化（CAC）。在该队列中，颈动脉 IMT 显着相关 具有 CAC 以及当前的 LDL 胆固醇和收缩压，但是 只有 14% 的颈动脉 IMT 变异可以用这些风险来解释 因素。该队列的父母已接受心血管发病率评估 和死亡率。在本申请中，研究人员建议这样做 (1)检查第三代，判断是否为后代 患有过早动脉粥样硬化和/或有家族史的队列成员 心血管疾病导致颈动脉IMT增加或危险因素升高； (2) 确定四年内颈动脉 IMT 进展的危险因素 队列； (3) 测量 IMT 增加的推定风险因素（血清学 肺炎衣原体或巨细胞病毒感染的证据，高灵敏度 C反应蛋白、纤维蛋白原、纤溶酶原激活剂抑制剂-1和 糖化血红蛋白）。研究人员表示，该研究 提供可识别受试者的信息的潜力 年轻时就有动脉粥样硬化的风险，并可能导致 在治疗之前采取干预措施来阻止或减缓动脉粥样硬化的进展 临床疾病的发展。