ADOLESCENT COAS--A TWIN FAMILY DESIGN

申请人摘要：这项建议的目的是研究其影响 父性酒精中毒对男性和女性结局和功能的影响 青春期后代。这一目标将通过比较以下数据来实现 878对和谐或不和谐双胞胎的青春期后代 因为酗酒。双胞胎家庭研究提供了重要的设计优势： 同卵双胞胎共享所有基因，异卵双胞胎共享一半基因，因此 研究人员登记了导致酒精中毒的遗传因素。第一 AIM将决定酗酒者的后代是否以及在多大程度上 双胞胎与非酒精双胞胎的后代相比，在以下方面有所不同； 酒精使用和滥用，精神病理学，学业成就，一般 结构化问卷测评心理社会能力与家庭关系 访谈和问卷调查。第二，这项研究将扩大到 收集生母饮酒信息的双胞胎家庭设计 使用和相关的母方和父方的精神病病理学。这将澄清 比较职能和结果数据之间的差异 酗酒父亲的子女和非酗酒父亲的子女 研究配偶/母亲的影响和双胞胎父亲的作用 精神病态与酒精中毒并存。母体效应可以是 受控，将进行分析，以评估 分类交配，酗酒的父母彼此结婚的倾向。 第三，为了了解父亲酗酒的机制 影响后代，家族性传播的三种调解模式 酒精中毒将被测试：越轨的社会化，负面影响 监管和药理脆弱性。这项拟议的研究使 使用独特的资源，因为双胞胎父亲都是 越南时代双胞胎注册处，并都参与了前几波 数据收集。当这些父亲的后代还在 青少年，宝贵的诊断、人口学和行为数据 使我们能够表征独立变量，如父亲的饮酒 病史、精神病学和人口统计变量，如收入和 教育和家庭结构。因此，拟议的研究获得了 作为第二波调查的优势是最大限度地 消息灵通的家庭已经被查明。

APPLICANT'S ABSTRACT: The objective of this proposal is to study the impact of paternal alcoholism on outcomes and functioning of male and female adolescent offspring. This aim will be accomplished by comparing data on adolescent offspring of 878 twins who are either concordant or discordant for alcoholism. Twin family studies afford important design advantages: identical twins share all their genes and fraternal twins share half so that genetic contributions to the onset of alcoholism are enrolled. The first aim will determine whether and to what extent the offspring of alcoholic twins compared to the offspring of non-alcoholic twins differ in regard to; alcohol use and abuse, psychopathology, academic achievement, general psyhcosocial competence and family relationships assessed by structured interviews and questionnaires. Second, the study will be extended to a twin-family design by collecting information on biological mothers' alcohol use and relevant maternal and paternal psychopathology. This will clarify differences between the comparative functioning and outcome data for the offspring of alcoholic fathers and offspring of non-alcoholic fathers by examining the role of spousal/maternal effects and twin father psychopathology co-morbid with alcoholism. Maternal effects can be controlled, and analysees will be conducted to assess the role of assortative mating, the tendancy of alcoholic parents to marry each other. Third, in order to understand the mechanisms whereby paternal alcoholism may impact offspring, three mediation models for familial transmission of alcoholism will be tested: deviant socialization, negative affect regulation and pharmacological vulnerability. This proposed research makes use of a unique resource because the twin fathers are all members of the Vietnam Era Twin Registry and have all participated in previous waves of data collection. While the offspring of these fathers are still adolescents, invaluable diagnostic, demogrphic and behavioral data have allowed us to characterize independent variables such as fathers' drinking history, psychopathology, and demographic variables such as income and education and family composition. Therefore, the proposed research gains the advantage of being a second wave investigation in which maximally informative families have already been ascertained.