FMRI OF VISUALLY MEDIATED EXPLICIT MEMORY IN AGING & AD

衰老过程中视觉介导的外显记忆的 FMRI

• 批准号: 6371976
• 负责人: JULIANNA BATES
• 金额: $ 12.02万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6371976
• 关键词: Alzheimer's disease; age difference; aging; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; cognition; functional magnetic resonance imaging; human old age (65+); human subject; memory; neural information processing; neurobiology; visual perception; young adult human (21-34)

DESCRIPTION (Adapted from the application): This is an application for a Mentored Research Scientist Development Award (MRSDA) entitled "fMRI of Visually Mediated Explicit Memory in Aging and AD". The overarching goal of this application is to utilize whole brain functional imaging techniques to study structure-function relationships subserving explicit memory in normal aging and Alzheimer's disease (AD). Functional MRI provides a unique opportunity to investigate the distributed anatomical systems engaged in this form of memory processing, which is known to be affected in normal aging, and is generally the earliest cognitive change detected in AD. An integrated series of studies is planned with the following goals: (1) to assess the relative contributions of visual perception and visual encoding to both memory performance and patterns of brain activation detected with fMRI in healthy young and elderly subjects and patients with mild AD, by studying visuospatial and visuofeature perception in both groups, (2) to study encoding of visuospatial and visuofeature stimuli with fMRI, and (3) to study effects of cognitive strategy on both visouspatial and visuofeature encoding processes in young, elderly and AD subjects. It is hypothesized that any beneficial effects of strategy will be reflected not only by chnages in memory performance but also by systematic changes in brain activation patterns. In addition, the candidate proposes to seek training in: (1) the basic neurobiology of memory, (2) cognitive psychology and neuropsychology, particularly as it pertains to aging and AD, (3) fMRI physics and analytic techniques, and (4) statistical approaches to both functional imaging and cognitive studies.

说明(改编自应用程序)： 这是一份导师研究科学家发展奖的申请表 (MRSDA)题为“衰老和AD中视觉调节外显记忆的功能磁共振成像”。 这个应用程序的首要目标是利用整个大脑功能 研究结构-功能关系的成像技术 正常衰老和阿尔茨海默病(AD)患者的外显记忆。功能磁共振 为研究分布式解剖学提供了一个独特的机会 从事这种形式的存储器处理的系统，已知 受正常衰老的影响，通常是最早的认知变化 在AD中检测到。 计划进行一系列综合研究，目标如下：(1) 评估视觉感知和视觉编码对 用fMRI检测小鼠的记忆表现和脑激活模式 健康的青年和老年受试者以及轻度AD患者，通过研究 两组的视觉空间知觉和视觉特征知觉，(2)学习编码 视觉空间和视觉特征刺激的功能磁共振成像，以及(3)研究效应 认知策略对视觉空间和视觉特征编码过程的影响 在年轻人、老年人和阿尔茨海默病患者中。据推测，任何有益的 策略的效果不仅体现在记忆的变化上 表现还受到大脑激活模式的系统性变化。 此外，候选人建议寻求以下方面的培训：(1)基本 记忆的神经生物学，(2)认知心理学和神经心理学， 尤其是与衰老和AD有关时，(3)功能磁共振物理学和分析 技术，以及(4)统计方法对功能成像和 认知研究。