Atypical Bacterial Infection as an Asthma Risk Factor

非典型细菌感染是哮喘的危险因素

• 批准号: 6321120
• 负责人: EVERETT RAND SUTHERLAND
• 金额: $ 12.01万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6321120
• 关键词: asthma; chlamydial disease; disease /disorder proneness /risk; human subject; mycoplasmal pneumonia; pathologic process; patient oriented research; questionnaires; respiratory disorder epidemiology; respiratory infections

DESCRIPTION (provided by applicant) Asthma, an inflammatory lung disease which causes chronic airflow obstruction, has a significant impact on the public health. There is mounting evidence that, in a subset of patients, pulmonary infection with mycoplasma and chlamydia is associated with chronic asthma. This study is designed to test the hypothesis that chronic infection with Mycoplasma pneumoniae or Chlamydia pneumoniae species is a risk factor for the development or worsening of asthma. A cohort of subjects with a history of clinically- and radiographically- evident M. pneumoniae and C. pneumoniae infection approximately nine years ago has been identified. All subjects in this cohort were tested for active mycoplasma or chlamydia infection with culture and polymerase chain reaction analysis of respiratory tract secretions, as well as serology. These patients will be studied using a respiratory symptoms questionnaire to determine the prevalence of asthma in this cohort nine years after the exposure. Following the questionnaire component of this study, additional testing will be performed on a subset of the cohort to further describe the clinical, physiologic, inflammatory and microbiologic characteristics of these patients. This series of investigations is designed to identify the importance of atypical bacterial infection to the development and clinical phenotype of asthma. An understanding of the association between mycoplasma and chlamydia species and asthma is critical to furthering our knowledge of asthma pathogenesis and provides the foundation on which interventions aimed at primary prevention may be based. The identification of infection as a risk factor for chronic asthma would be a significant advance in our ability to predict which patients have an increased likelihood of developing asthma and would facilitate the design and implementation of targeted attempts to reduce asthma incidence. The investigations described herein will be conducted as part of a comprehensive career development program in the methods of patient-oriented research. With this award, the candidate will become educated in the methods of patient-oriented research as part of a Master in Public Health degree program at the Harvard School of Public Health and will then apply the skills learned in the didactic setting to the implementation of this research protocol. The candidate is intent upon using this award to support a career development program that will ensure his success as an academic physician-scientist with a focus on patient-oriented research in diseases of the lungs.

描述（由申请人提供） 哮喘是一种引起慢性气流阻塞的炎症性肺病， 对公众健康有重大影响。越来越多的证据 在一部分患者中， 衣原体与慢性哮喘有关。这项研究旨在测试 肺炎支原体或衣原体慢性感染假说 肺炎菌种是发展或恶化的危险因素 哮喘一组具有临床和 X线摄影明显M.肺炎衣原体和C.肺炎菌感染 大约九年前被发现。该队列中的所有受试者 用培养物检测活动性支原体或衣原体感染， 呼吸道分泌物的聚合酶链反应分析，以及 血清学这些患者将使用呼吸道症状进行研究 问卷调查，以确定该队列9年的哮喘患病率 曝光后。在本研究的问卷调查部分之后， 将对队列的一个子集进行额外的测试，以进一步 描述临床、生理、炎症和微生物 这些患者的特点。 这一系列调查旨在确定以下方面的重要性： 非典型细菌感染的发展和临床表型 哮喘支原体与衣原体关系的探讨 物种和哮喘是至关重要的，以促进我们的知识哮喘 发病机制，并提供了基础上的干预措施，旨在 一级预防是基础。将感染识别为风险 慢性哮喘的因素将是我们的能力的一个重大进步， 预测哪些患者患哮喘的可能性增加， 将有助于设计和实施有针对性的尝试， 哮喘发病率 本文所述的调查将作为 以病人为中心的综合职业发展计划 research.有了这个奖项，候选人将成为教育的方法， 作为公共卫生硕士学位的一部分， 项目在哈佛公共卫生学院，然后将应用技能 在教学环境中学到的，以实施这项研究 议定书候选人打算利用这个奖项来支持职业生涯 发展计划，这将确保他作为一个学术物理学家，科学家的成功 专注于以患者为导向的肺部疾病研究。