Radionuclide imaging and therapy dosimetry system

描述（由申请人提供）：本第一阶段提案的目标是 确定科学，技术和商业价值和可行性， 一个综合的商业治疗计划和剂量测定系统（RTDS）， 放射性核素治疗和放射性核素成像，特别是用于 放射免疫治疗（AlT）。在临床和实验性RIT中， 正常器官和肿瘤中的吸收剂量是获得 了解正常组织毒性和肿瘤剂量反应。这个项目 将导致用户友好的软件程序，允许物理学家/医生， 在AlT治疗期间进行剂量测定分析。该软件包将 集成到CMS FOCUS 3D放射治疗计划系统中， 器官和肿瘤的勾画，CT和核成像的配准 医学图像集，以及吸收剂量的估计和可视化， 关键组织。用户可以选择购买RTDS模块， 为接受治疗的患者进行治疗计划和剂量测定计算 放射性核素成像和/或治疗。这将是第一个商业化的 这种治疗计划系统将得到充分支持， CMS，Inc.更重要的是，该项目将提供一个总体框架， 进行AlT剂量测定和标准化剂量测定的机会 技术和方法。 拟议的商业应用： 该项目将导致一个用户友好的软件程序，使物理学家/医生在放射性核素治疗和放射性核素成像程序进行剂量测定分析。这将是第一个商业上可用的和完全支持的系统。它将被广泛用于医院和医疗中心进行放射性核素治疗和放射性核素成像，特别是放射免疫治疗（RIT）治疗。

DESCRIPTION (Provided by Applicant): The objective of this Phase I proposal is to determine the scientific, technical, and commercial merit and feasibility of an integrated commercial treatment planning and dosimetry system (RTDS) for radionuclide therapy and radionuclide imaging, especially for radioimmunotherapy (AlT). In clinical and experimental RIT, knowledge of the absorbed dose in normal organs and tumors is essential in gaining an understanding of normal tissue toxicity and tumor dose response. This project will lead to a user-friendly software program allowing physicist/physicians to perform dosimetry analysis during AlT treatment. The software package will be integrated into the CMS FOCUS 3D radiation treatment planning system, allowing the delineation of organs and tumors, the co-registration of CT and nuclear medicine image sets, and the estimation and visualization of absorbed dose in critical tissues. User will have the option to purchase the RTDS module to perform treatment planning and dosimetry calculation for patients receiving radionuclide imaging and/or therapy. It will be the first commercially available treatment planning system of this kind and will be fully supported by CMS, inc. More importantly, this project will provide a general framework to perform AlT dosimetry and the opportunity to standardize the dosimetry technique and methodology used in RIT. PROPOSED COMMERCIAL APPLICATIONS: This project will lead to a user-friendly software program allowing physicist/physicians to perform dosimetry analysis during radionuclide therapy and radionuclide imaging procedures. It will be the first commercially available and fully supported system. It will be widely used by hospitals and medical centers that perform radionuclide therapy and radionuclide imaging, especially radioimmunotherapy (RIT) treatment.