IMPACT OF CHILDHOOD OBESITY AND GROWTH ON MORTALITY

描述：(改编自《调查者摘要》) 儿科人群中肥胖的患病率和严重程度将很快 导致与以下疾病相关的许多疾病的发病率增加 成年后的肥胖。尽管青年时期的肥胖与成人有关 肥胖症与肥胖症相关的发病率，人们对其具体情况知之甚少 儿童时期不同时期肥胖的贡献。相关 早熟和生长加速等现象也可能影响 后来的健康状况却鲜有人探索。 本项目将考察增长动力的影响，重点放在 儿童、青春期和成年期的偶发肥胖症 全因死亡和特定原因死亡。一项回溯性队列研究将 对1842名最初在20世纪20年代和30年代进行研究的受试者进行研究 波士顿附近，作为第三次哈佛增长研究的一部分。这一早期的增长 这项研究是有史以来规模最大的身体发育研究之一。 承担了。12年来获得的年度人体测量数据 将允许表征超重和肥胖的开始，增量 身高和体重速度，以及成熟的时机。其他后续行动 在1968年和1988年进行的研究将提供以下信息 成人体重状况。这些信息将与生存和 死亡证明中的死因。据推测， 与肥胖相关的死亡率在儿童期发病和 青春期起病与成人起病超重相比。它也是 假设加速生长和早熟进一步增加 死亡风险。 调查人员表示，这项拟议的研究是例外的，因为 仔细收集了儿童和青少年的成长数据，并 随访期长。他们指出，没有其他可比的数据 美国存在一个基于社区的样本，加在一起，早期 生长、成人随访和死亡率数据特别适合于 描述超重开始的时间与其他因素的关系 生长特征对全因和特定原因死亡率的影响。

DESCRIPTION: (Adapted from Investigator's Abstract) Rapid increases in the prevalence and severity of obesity in the pediatric population will soon cause an increase in the incidence rate in many diseases associated with obesity in adulthood. Although obesity in youth is associated with adult obesity and obesity-related morbidity, little is known of the specific contribution of obesity at different points in childhood. Related phenomena, such as early maturation and accelerated growth, may also affect later health but have rarely been explored. This project will examine the impact of growth dynamics, with primary focus on incident obesity in childhood, adolescence and adulthood, and on all-cause and cause-specific mortality. A retrospective cohort study will be conducted of 1,842 subjects originally studied in the 1920s and 1930s near Boston as a part of the Third Harvard Growth Study. This early growth study represents one of the largest studies of physical growth ever undertaken. The annual anthropometric measurements obtained over 12 years will allow characterization of onset of overweight and obesity, incremental height and weight velocity, and maturational timing. Additional follow-ups of this cohort, conducted in 1968 and 1988, will provide information on adult weight status. This information will be related to survival and to cause of death from death certificates. It is hypothesized that obesity-related mortality is greater for childhood-onset and adolescent-onset compared to adult-onset overweight. It is also hypothesized that accelerated growth and early maturation further increase mortality risk. The investigators state that the proposed study is exceptional because childhood and adolescent growth data were carefully collected and the follow-up period was long. They point out that no other comparable data on a community-based sample in the U.S. exists, and that together, the early growth, adult follow-up, and mortality data are uniquely suited to characterize the relationship of the timing of overweight onset and other growth characteristics to all-cause and cause-specific mortality.