IMPACT OF CHILDHOOD OBESITY AND GROWTH ON MORTALITY

描述：（改编自研究者摘要） 儿童肥胖症的患病率和严重程度 导致许多疾病的发病率增加， 成年后的肥胖 虽然青少年的肥胖与成人 肥胖和肥胖相关的发病率，很少有人知道的具体 肥胖在儿童时期不同阶段的作用。 相关 早熟和加速生长等现象也可能影响 后来的健康，但很少被探索。 本项目将研究增长动态的影响，主要关注 儿童、青少年和成年期的偶发性肥胖， 全因和特定原因死亡率。 一项回顾性队列研究将 最初在20世纪20年代和30年代研究的1，842名受试者中进行 作为第三次哈佛增长研究的一部分。 这种早期生长 这项研究是有史以来规模最大的身体发育研究之一 进行。 12年来获得的年度人体测量数据 将允许表征超重和肥胖的发作，增量 身高体重增长速度和成熟时间 额外的后续行动 在1968年和1988年进行的这一队列研究将提供以下信息： 成人体重状况 这些信息将与生存和 死亡证明上的死因 它是假设 儿童期发病的肥胖相关死亡率较高， 与成人超重相比， 也是 假设加速生长和早熟进一步增加 死亡风险。 研究人员表示，拟议的研究是例外的，因为 儿童和青少年的生长数据被仔细收集， 随访时间较长。 他们指出，没有其他可比数据， 在美国，有一个以社区为基础的样本， 生长、成人随访和死亡率数据特别适合于 描述超重发生的时间和其他 生长特征与全因和特定原因死亡率之间的关系。

DESCRIPTION: (Adapted from Investigator's Abstract) Rapid increases in the prevalence and severity of obesity in the pediatric population will soon cause an increase in the incidence rate in many diseases associated with obesity in adulthood. Although obesity in youth is associated with adult obesity and obesity-related morbidity, little is known of the specific contribution of obesity at different points in childhood. Related phenomena, such as early maturation and accelerated growth, may also affect later health but have rarely been explored. This project will examine the impact of growth dynamics, with primary focus on incident obesity in childhood, adolescence and adulthood, and on all-cause and cause-specific mortality. A retrospective cohort study will be conducted of 1,842 subjects originally studied in the 1920s and 1930s near Boston as a part of the Third Harvard Growth Study. This early growth study represents one of the largest studies of physical growth ever undertaken. The annual anthropometric measurements obtained over 12 years will allow characterization of onset of overweight and obesity, incremental height and weight velocity, and maturational timing. Additional follow-ups of this cohort, conducted in 1968 and 1988, will provide information on adult weight status. This information will be related to survival and to cause of death from death certificates. It is hypothesized that obesity-related mortality is greater for childhood-onset and adolescent-onset compared to adult-onset overweight. It is also hypothesized that accelerated growth and early maturation further increase mortality risk. The investigators state that the proposed study is exceptional because childhood and adolescent growth data were carefully collected and the follow-up period was long. They point out that no other comparable data on a community-based sample in the U.S. exists, and that together, the early growth, adult follow-up, and mortality data are uniquely suited to characterize the relationship of the timing of overweight onset and other growth characteristics to all-cause and cause-specific mortality.