RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

多囊卵巢综合症女性患冠心病的风险

• 批准号: 6389130
• 负责人: Evelyn O. Talbott
• 金额: $ 49.46万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6389130
• 关键词: angiocardioultrasonography; atherosclerosis; blood coagulation; blood pressure; body composition; cardiovascular disorder epidemiology; carotid artery; clinical research; computed axial tomography; coronary disorder; coronary vessels; disease /disorder proneness /risk; female; high density lipoproteins; human subject; insulin; longitudinal human study; low density lipoprotein; mass screening; pathologic process; photon absorptiometry; polycystic ovary syndrome; triglycerides; vascular endothelium; vascular resistance

DESCRIPTION: (Adapted from the Investigator's Abstract) Polycystic ovary syndrome (PCOS), characterized by chronic anovulation, hyperandrogenism, and insulin resistance, is estimated to affect four percent to eight percent of all women. In 1992, the investigators initiated the first large-scale study of cardiovascular risk factors in women with PCOS (1992-1994). They recruited 244 women with PCOS and 244 age-, race- and neighborhood-matched controls age (19-50 years of age) and determined that PCOS cases had a profile that conferred increased cardiovascular risk (increased LDLc, triglycerides, and waist/hip ratio, obesity, decreased HDLc, hyperinsulinemia, and increased diastolic and systolic blood pressure). During phase II, (1996-99) they investigated the prevalence of subclinical atherosclerosis (SCA) of the carotid arteries in women 30+ years of age from the original cohort. In preliminary analyses, PCOS cases 45+ years had significantly higher mean intima-media wall thickness (IMT) than controls (0.75mm vs. 0.70mm, p<.02). The investigators state that this well established cohort provides a unique opportunity to extend their study of CHD risk in women with PCOS by conducting more powerful longitudinal studies of SCA. The specific aims of the present study are to 1) recruit and screen 160 PCOS cases and 160 controls >=40 years from the original cohort to determine if PCOS cases have greater initial coronary or aortic calcification and/or greater progression during years 4 and 5, 2) evaluate the progression of carotid atherosclerosis over a 5-year period of PCOS cases and controls >=40 years who participated in Phase II of the study, 3) evaluate whether CHD risk factors can be linked to the extent of coronary and aortic calcification within cases and controls, 4) evaluate vascular stiffness in PCOS cases and controls and determine CHD risk factors for aortic stiffness, and 5) evaluate endothelial function in PCOS cases and controls and changes over five years. CHD risk factors will include: HDLt, LDLc, triglycerides, glucose, insulin, Lp(a), PAI-1, blood pressure, and anthropometric measures. Information will be obtained on medical, reproductive and physical activity history. The investigators state that this study has the potential to identify the determinants of early SCA in this high-risk group of women and has important implications for primary as well as secondary prevention.

描述：(改编自《调查者摘要》)多囊卵巢 综合征(PCOS)，以慢性无排卵、高雄激素血症为特征， 胰岛素抵抗，估计有4%到8%的人会受到影响 女人。1992年，研究人员启动了第一次大规模的 多囊卵巢综合征妇女的心血管危险因素(1992-1994)他们招募了244人 患有多囊卵巢综合征的女性和244名年龄、种族和邻里匹配的对照年龄 (19-50岁)，并确定多囊卵巢综合征患者的特征 导致心血管风险增加(低密度脂蛋白、甘油三酯和 腰臀比、肥胖、高密度脂蛋白降低、高胰岛素血症和 舒张压和收缩压)。在第二阶段，(1996-99) 调查颈动脉亚临床动脉粥样硬化(SCA)的患病率 动脉来自30岁以上的女性，来自最初的队列。在预赛中 分析显示，45岁以上的多囊卵巢综合征患者的平均内膜-中膜厚度显著较高 厚度(IMT)高于对照组(0.75 mm vs.0.70 mm，p&lt；0.02)。调查人员 声明，这一成熟的群体提供了一个独特的机会来扩大 他们通过进行更有力的研究来研究多囊卵巢综合征患者的冠心病风险 SCA的纵向研究。本研究的具体目的是：1) 招募和筛查160例多囊卵巢综合征患者和160名对照&=40年 确定多囊卵巢综合征患者初始冠状动脉或主动脉是否较大的队列 第4年和第5年钙化和/或进展更快，2)评估 多囊卵巢综合征患者颈动脉粥样硬化的5年进展 对照组=40年参与第二阶段研究的人，3)评估 冠心病危险因素是否与冠状动脉和主动脉病变程度有关 病例和对照中的钙化：4)评估多囊卵巢综合征患者的血管硬度 病例和对照，并确定主动脉僵硬的冠心病危险因素，以及5) 评估多囊卵巢综合征患者和对照的内皮功能，以及五年以上的变化 好几年了。冠心病危险因素包括：高密度脂蛋白、低密度脂蛋白、甘油三酯、葡萄糖、 胰岛素、脂蛋白(A)、纤溶酶原激活物-1、血压和人体测量。信息 将获得有关医疗、生殖和体力活动史的信息。这个 调查人员表示，这项研究有可能确定 在这一高危人群中早期SCA的决定因素和重要的 对初级预防和二级预防的影响。