Understanding the mechanistic uptake and exploring the translation of novel amino acid based ion pair complexes

了解新型氨基酸离子对复合物的吸收机制并探索转化

• 批准号: 1655352
• 金额: --
• 依托单位: Aston University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1655352
• 关键词: Understanding; mechanistic; uptake; exploring; translation

The Project aims to study the cellular mechanism of enhancement of permeability of model poorly permeable drugs in the presence of different concentration of oppositely charged amino acids. The project involves the application of various techniques including drug permeability assessment, physical characterisation such as solubility assessment, differential calorimetric analysis as well as microbial assays such as rate kill studies and drug uptake assays in microbes. The project will provide expertise in interdisciplinary sciences involving physical chemistry, microbiology and drug formulation.

本项目旨在研究在不同浓度的带相反电荷的氨基酸存在下，模型低渗透性药物通透性增强的细胞机制。该项目涉及各种技术的应用，包括药物渗透性评估、物理表征（如溶解度评估）、差热分析以及微生物分析（如速率杀死研究和微生物的药物摄取分析）。该项目将提供涉及物理化学、微生物学和药物配方的跨学科科学专业知识。