Total Synthesis of an Anti-HIV Natural Product

包含大量小分子的文库的产生，与高通量筛选方法相结合，在寻找新药方面有很大的用途。然而，天然产物作为生物活性结构的来源对制药和农业化学工业仍然很重要。此外，它们还可以帮助确定新的目标，以进行进一步的研究。合成有机化学在通过天然产物及其类似物的合成和修饰来帮助这一追求方面处于独特的地位。在本提案中，我们的目标是合成一种最近分离的天然产物，该天然产物已被证明具有抗HIV活性，可对抗目前使用的治疗方法。关键断开将使用小的有机分子作为催化剂，以能够快速有效地构建复杂的分子结构。作为牛津大学生物学和医学博士培训中心合成的一部分，该项目拥有众多的制药和农用化学工业合作伙伴。这个开放的系统允许自由交流想法，以帮助项目。

The production of libraries containing vast numbers of small molecules, in combination with high-throughput screening methods, has found much use in the search for new drugs. However, natural products remain important to the pharmaceutical and agrochemical industries as a source of biologically-active structures. In addition, they can assist in the identification of novel targets for further investigation. Synthetic organic chemistry is in a unique position to assist this pursuit through the synthesis and modification of natural products and their analogues.In this proposal, we aim to synthesise a recently isolated natural product that has been shown to possess anti-HIV activity against strains resistant to currently used treatments. The key disconnection would use a small organic molecule as a catalyst to enable rapid and efficient construction of the complex molecular structure.As part of the Synthesis for Biology and Medicine Doctoral Training Centre in Oxford, this project has numerous pharmaceutical and agrochemical industrial partners. This open-access system enables free exchange of ideas to assist the project.