Role of LINEs and their binding proteins in brain evolution

LINEs 及其结合蛋白在大脑进化中的作用

• 批准号: 1764955
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1764955
• 关键词: Role; LINEs; their; binding; proteins

A large proportion of mammalian genome is made up of retrotransposons. LINEs are a major class of retrotransposable elements and their functional roles are still poorly understood. Previous data from the Ule lab has identified a series of RNA binding proteins which are likely to be important regulators of LINE derived transcripts, but about which almost nothing is known. This project will focus on how LINEs and their binding proteins influence cellular decision making, particularly of cell fate decisions in brain development. We hypothesise that variation in LINEs between species has contributed to their divergent speciation.

哺乳动物基因组的很大一部分由反转录转座子组成。LINE是一类主要的逆转录转座因子，其功能作用仍然知之甚少。Ule实验室先前的数据已经确定了一系列RNA结合蛋白，这些蛋白可能是LINE衍生转录物的重要调节因子，但对它们几乎一无所知。该项目将重点关注LINES及其结合蛋白如何影响细胞决策，特别是大脑发育中的细胞命运决定。我们假设，物种之间的LINES的变化，有助于他们的不同物种形成。

项目成果

Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing.

• DOI: 10.1016/j.molcel.2018.09.033
• 发表时间: 2018-11-01
• 期刊: Molecular cell
• 影响因子: 16
• 作者: Blazquez L;Emmett W;Faraway R;Pineda JMB;Bajew S;Gohr A;Haberman N;Sibley CR;Bradley RK;Irimia M;Ule J
• 通讯作者: Ule J