"Understanding Biomaterials using Ultrafast Two- Dimensional Infrared Spectroscopy (2D-IR)"

研究重点在于阐明生物分子相互作用的基本物理原理和运行机制，是充分理解和利用生物分子相互作用的关键。生物分子的结构和功能之间的密切关系，以及任何复杂问题，都需要一套实验方法，以便从给定系统中提取尽可能多的信息。本课题将探索利用超快二维红外光谱仪（2D-IR）（一种非线性红外光谱）来研究分子结构与功能之间的关系。特别是该项目将探索使用这种方法来研究微妙的重排和氢键及其动力学。该项目将研究三种主要的重要生物分子：角蛋白和角蛋白相关蛋白（KAP），重要的普遍存在的天然结构蛋白，屏障糖蛋白粘蛋白（一类很难用大多数“正常”方法研究的分子），以及在食品和冰淇淋结构中重要的碳水化合物类，它们与糖蛋白构成类似的问题。

The research focuses on the elucidation of the underlying physical principles and operation mechanisms of biological molecules is key for a full understanding and exploitation of such interactions. The close relationship between the structure and function of biological molecules and, as with any complex problem, a suite of experimental approaches is required in order to extract as much information as possible from a given system. This proposal will explore the use ultrafast of Two-dimensional infrared spectrometer (2D-IR) (a nonlinear infrared spectroscopy) to examine the relationship between structure and function of molecules. In particular the project will explore the use of this approach to investigate the subtle rearrangements and hydrogen bonding and there dynamics. This project will study three main important classes of biological molecules, keratin and Keratin associated proteins (KAP's), important ubiquitous natural structural proteins, the barrier glycoprotein Mucin a class of molecules very difficult to study by most 'normal' methods and classes of carbohydrates important in food and ice cream structuring which pose similar problems to glycoproteins.