CONTRIBUTIONS OF CHOROID PLEXUS TO HIV NEUROPATHOGENESIS

描述（改编自申请人的摘要）：本申请涉及 脑脊液中HIV-1和免疫激活物是否真实反映脑功能问题 实质感染具体而言，该提案调查了 脉络丛（CP）和脑膜的。该提案的目的是（1）。到 确定CP是否是CSF中HIV的来源; 2）.确定 CP上皮细胞和成纤维细胞对 HIV; 3）检查来自HIV感染患者的CP和脑膜组织， 没有神经系统疾病;和4）。为了确定CP是否代表 HIV感染者CSF中增加的一些分子的重要来源 个体一系列适当的假设强调了这些目标 和需要解决的问题。

Description (adapted from applicant's abstract): This application addresses the issue of whether HIV-1 and immune activators in CSF truly reflect brain parenchymal infection. Specifically, the proposal investigates the contribution of the choroid plexus (CP) and meninges. The Aims of the proposal are 1). To determine if the CP is a source of HIV in CSF; 2). To determine the susceptibility and permissivity of CP epithelial and fibroblastoid cells to HIV; 3) Examine CP and meningeal tissues from HIV-infected patients with and without neurological disease; and 4). To determine if the CP represents a significant source of some of the molecules increased in CSF in HIV-infected individuals. These Aims are underscored by a series of appropriate hypotheses and questions to be addressed.