Computational modelling of separation processes for green continuous pharmaceutical manufacturing

绿色连续制药分离过程的计算模型

• 批准号: 1783036
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1783036
• 关键词: Computational; modelling; separation; processes; green

Continuous pharmaceutical manufacturing (CPM) has been shown to provide significant cost savings and reduction of material requirements and waste compared to the currently used, yet inefficient, batch methods. With the highest research and development costs of all industrial sectors, and historically increasing commercialisation costs, technological innovation is essential for pharmaceutical firms to remain profitable and sustainable. For the benefits of CPM to be realised by industry, demonstration of its feasibility and viability is paramount. The proposed PhD project looks to focus on the environmental benefits of CPM by process modelling and simulation of drug purification and separation stages. Non-linear programming of separation processes using rigorous thermodynamic modelling will be implemented to provide insights into the best separation process options. This will showcase the green benefits of CPM over the current batch paradigm, and contribute work to further the switch from batch to continuous manufacturing in the pharmaceutical industry today.

连续制药（CPM）已被证明提供显着的成本节约和减少材料的要求和浪费相比，目前使用的，但效率低下，批量方法。由于所有工业部门的研发成本最高，商业化成本也在历史上不断增加，技术创新对于制药公司保持盈利和可持续发展至关重要。要使行业实现CPM的好处，证明其可行性和可行性至关重要。拟议的博士项目着眼于通过药物纯化和分离阶段的过程建模和模拟来关注CPM的环境效益。将采用严格的热力学模型对分离工艺进行非线性规划，以便深入了解最佳分离工艺方案。这将展示CPM相对于当前批处理模式的绿色优势，并为当今制药行业从批处理到连续生产的进一步转变做出贡献。

项目成果

Technoeconomic Evaluation of Multiple Mixed Suspension-Mixed Product Removal (MSMPR) Crystallizer Configurations for Continuous Cyclosporine Crystallization

用于连续环孢素结晶的多种混合悬浮液-混合产物去除 (MSMPR) 结晶器配置的技术经济评价

• 发表时间: 2017
• 期刊: Organic Process Research & Development
• 影响因子: 3.4
• 作者: Diab S.

28th European Symposium on Computer Aided Process Engineering

第 28 届欧洲计算机辅助过程工程研讨会

• 发表时间: 2018
• 作者: Diab S.

Process modelling, simulation and technoeconomic evaluation of separation solvents for the continuous pharmaceutical manufacturing (CPM) of diphenhydramine

苯海拉明连续制药 (CPM) 分离溶剂的工艺建模、模拟和技术经济评估

• 发表时间: 2017
• 期刊: Organic Process Research & Development
• 影响因子: 3.4
• 作者: Diab S.

Technoeconomic Mixed Integer Nonlinear Programming (MINLP) optimization for design of Liquid-Liquid Extraction (LLE) cascades in continuous pharmaceutical manufacturing of atropine

阿托品连续制药生产中液液萃取 (LLE) 级联设计的技术经济混合整数非线性规划 (MINLP) 优化

• DOI: 10.1002/aic.16738
• 发表时间: 2019
• 期刊: AIChE Journal
• 影响因子: 3.7
• 作者: Diab S

Process modelling, design and technoeconomic Liquid-Liquid Extraction (LLE) optimisation for comparative evaluation of batch vs. continuous pharmaceutical manufacturing of atropine

• DOI: 10.1016/j.compchemeng.2018.12.028
• 发表时间: 2019-05
• 期刊: Comput. Chem. Eng.
• 作者: Samir Diab;Nikolaos Mytis;A. Boudouvis;Dimitrios I. Gerogiorgis