Helicases: Structure, Function, & Roles in Human Disease

解旋酶：结构、功能、

• 批准号: 6360057
• 负责人: STEVEN W MATSON
• 金额: $ 2.22万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6360057
• 关键词: aging; enzyme structure; helicase; meeting /conference /symposium; protein structure function; travel

DESCRIPTION (provided by applicant): This application is for partial funding for the 2001 FASEB Summer Conference on "Helicases: Structure, Function and Roles in Human Disease" to be held on July 7-12, 2001 at the Vermont Academy in Saxtons River, Vermont. The conference will be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB). There will be nine major scientific sessions, each session including, on average, five 30 minute oral presentations. There will be two poster sessions, each lasting two days. Helicases play essential roles in a wide range of important biological processes including DNA replication, repair, recombination, transcription, splicing and translation. In addition, it has recently been shown that several inherited human diseases (e.g. Bloom syndrome, Werner syndrome, Cockayne syndrome and Xeroderma pigmentosum) are caused by mutations in specific helicases. Thus, defects in genes encoding helicases are associated with genomic instability, an increased incidence of cancer, and the molecular biology of aging. The topics to be included for discussion are: helicase structure; helicase function and mechanism; DNA helicases in DNA replication, DNA helicases in DNA repair and recombination, RNA helicases in transcription, splicing, RNA stability and transport, RNA helicases in translation and ribosome hiegenesis; helicases as part of macromolecular machines; helicases in vital replication; and helicases in cancer and aging. The meeting will consider both RNA and DNA helicases from sources ranging from viruses and bacteria to eukaryotic cells including human helicases. The goal of this meeting is to bring together biochemists, structural biologists, geneticists and those with a more clinical view to share information. This field is an extremely rapid pace with new information on mechanism, structure and the role of helicases in human disease reported on a weekly basis. This is the first FASEB conference on this subject; in fact, it is the first meeting devoted exclusively to helicases to be held in this country.

描述（申请人提供）：本申请为部分申请 为2001年FASEB夏季会议“解旋酶：结构， 人类疾病的功能及角色”研讨会将于二零零一年七月七日至十二日在 佛蒙特州萨克顿河的佛蒙特学院。会议将在 由美国实验生物学学会联合会赞助 （FASEB）。将有九个主要的科学会议，每一个会议包括， 平均5次30分钟的口头报告。将有两张海报 每届会议为期两天。 解旋酶在许多重要的生物学过程中起着重要的作用。 包括DNA复制，修复，重组，转录， 拼接和翻译。此外，最近有证据表明， 遗传性人类疾病（例如Bloom综合征、Werner综合征、Cockayne综合征） 综合征和着色性干皮病）是由特异性 解旋酶因此，编码解旋酶的基因中的缺陷与 基因组的不稳定性，癌症发病率的增加， 衰老生物学讨论的主题包括：解旋酶 结构;解旋酶功能和机制; DNA复制中的DNA解旋酶， DNA修复和重组中的DNA解旋酶，转录中的RNA解旋酶， 剪接，RNA稳定性和转运，翻译中的RNA解旋酶， 核糖体遗传;解旋酶作为大分子机器的一部分;解旋酶 以及癌症和衰老中的解旋酶。会议将 考虑RNA和DNA解旋酶来源于病毒和 细菌至真核细胞，包括人解旋酶。 这次会议的目标是汇集生物化学家，结构， 生物学家，遗传学家和那些更临床的观点分享 信息.这一领域是一个非常迅速的步伐与新的信息， 解旋酶的机制、结构及其在人类疾病中的作用 每周的基础上。 这是FASEB关于这个主题的第一次会议;事实上，这是第一次。 在这个国家举行的专门讨论解旋酶的会议。