2001 Antimicrobial Peptides Gordon Conference

描述(申请人提供)：第三届戈登研究半年度 抗菌肽会议将于3月在加利福尼亚州文图拉举行 2001年18-23日。具有抗药性的微生物的出现 对内源性抗菌物质研究的浓厚兴趣。 抗菌肽是一种内源性基因编码的抗生素，在大多数 生命形式，包括单细胞生物、植物、无脊椎动物和 脊椎动物(包括人类)。越来越多的证据表明， 这些多肽在各种生物环境中的天然宿主防御。在……里面 除了它们针对破坏微生物的杀菌作用之外 膜功能方面，最近的研究表明，许多哺乳动物的多肽 也具有受体介导的炎症相关活动，支持 假设它们是关键的多功能宿主防御效应器分子。 更多关于它们(S)在宿主固有防御反应中的作用的知识可能会 有助于我们更全面地了解心力衰竭的病理生理学。 几种人类疾病，包括囊性纤维化，通过性传播 疾病、牙周炎、炎症性肠病等。这个 会议将聚焦于这一相对年轻、迅速扩张的 多学科研究领域。课程将分为9个环节 口头陈述和两次海报会议；将敦促所有参与者 呈现这些格式中的一种或另一种口头陈述将 包括主旨演讲(Jules Hoffmann教授，题为《天生》 免疫力：进化论观点“)，讲座(20分钟+10分钟 讨论)，和简短的演讲(选自关键海报)，并注意 包括高级、初级和学生级别的科学家。简短的口头陈述 将由一名新成立的研究生的接受者提交 奖品。会议讨论的主题包括：膜的机制 相互作用、多肽结构、新方法、先天功能 免疫、微生物耐药机制、生物学的新视角 抗菌肽的活性和功能、实用用途。充足的时间 与会者之间的有组织的讨论和非正式的互动 已被包括在内。此外，还将有一场会议专门讨论“当前 争议“，这将允许在裁剪会议上深入讨论主题 边缘电流调查。其组织理念是鼓励 多元化参与，并保持对性别问题的关注，朱尼尔 科学家、少数民族和身体有缺陷的个人。

DESCRIPTION (provided by applicant): The third semi-annual Gordon Research Conference on Antimicrobial Peptides will meet in Ventura, California, March 18-23, 2001. The emergence of antibiotic-resistant microorganisms has heightened interest in the study of endogenous antimicrobial substances. Antimicrobial peptides are endogenous gene-encoded antibiotics found in most life forms, including unicellular organisms, plants, invertebrates and vertebrates (including humans). Accumulating evidence points to a key role for these peptides in innate host defense in a variety of biological settings. In addition to their microbicidal action directed at disruption of microbial membrane functions, recent studies have revealed that many mammalian peptides also have receptor-mediated inflammation-associated activities, supporting the hypothesis that they are key multifunctional host defense effecter molecules. More knowledge of their role(s) in innate host defense responses will likely contribute to our more complete understanding of the pathophysiology of several human diseases, including cystic fibrosis, sexually transmitted diseases, periodontitis, inflammatory bowel disease, and others. The conference will focus on this relatively young, rapidly expanding multidisciplinary field of study. The program will be divided into 9 sessions of oral presentations and two poster sessions; all participants will be urged to present one or the other of these formats. The oral presentations will include a keynote address (by Professor Jules Hoffmann, entitled, "Innate immunity: evolutionary perspectives."), lectures (20 minutes + 10 minute discussion), and short talks (selected from key posters), with attention to include senior, junior and student level scientists. A short oral presentation will be presented by the recipient of a newly established Graduate Student Award. The themes addressed in the sessions include: Mechanisms of Membrane Interactions, Peptide Structure, Novel Methodologies, Functions in Innate Immunity, Microbial Resistance Mechanisms, New Perspectives on Biological Activities and Function, Practical uses For Antimicrobial Peptides. Ample time for organized discussion and informal interaction amongst participants has been included. In addition, one session will be devoted to "current controversies", which will allow in depth discussion of topics at the cutting edge current investigation. The organizational philosophy is to encourage diverse participation, and maintain an eye towards gender issues, junior scientists, minorities and individuals with physical limitations.