TOOLS FOR HETEROGENEITY ANALYSIS OF CLINICAL TRIALS

临床试验异质性分析工具

• 批准号: 6294215
• 负责人: Jonathan Levine
• 金额: $ 9.99万
• 依托单位: LINCOLN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-21 至 2002-07-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6294215
• 关键词: clinical trials; computer assisted patient care; computer data analysis; computer human interaction; computer program /software; computer system design /evaluation; data collection methodology /evaluation; interactive multimedia; statistics /biometry

DESCRIPTION: The overall goal of this research is to develop interactive software for performing sophisticated heterogeneity analysis of clinical trials involving multiple centers and/or multiple strata. In particular, the software will enable the user to explore how different strategies for combining treatment effects across strata (e.g. center, sex, race, disease severity, etc.) affect the resulting estimate of the overall treatment effect. By providing tools for systematically examining the magnitude and precision of multiple estimates of the overall treatment effect (based on the different combining strategies), the software will support the researcher in assessing the impact of any observed heterogeneity with regard to overall inference. This can also be viewed as a data-mining tool, enabling the researcher to interactively search for different possible structures in the data set. The ultimate benefit of successful development and deployment of this technology is improvement in health care by enabling researchers to better understand the nature of heterogeneity that may be encountered in clinical trials, thereby increasing the understanding of the overall safety and efficacy of drug products. PROPOSED COMMERCAIL APPLICATION: NOT AVAILABLE

描述：本研究的总体目标是开发互动性