TOOLS FOR HETEROGENEITY ANALYSIS OF CLINICAL TRIALS

描述：本研究的总体目标是开发交互式 用于执行复杂的临床试验异质性分析的软件 涉及多个中心和/或多个地层。特别是，该软件 将使用户能够探索不同的策略如何组合 跨阶层的治疗效果(例如，中心、性别、种族、疾病严重程度、 等)影响由此产生的整体治疗效果的估计。通过 提供工具，用于系统地检查 对总体治疗效果的多重估计(基于不同的 结合策略)，该软件将支持研究人员评估 任何观察到的异质性对总体推断的影响。这 也可以被视为数据挖掘工具，使研究人员能够 在数据集中交互搜索不同的可能结构。 成功开发和部署的最终好处是 技术正在改善医疗保健，使研究人员能够更好地 了解临床上可能遇到的异质性的性质 试验，从而增加了对总体安全性和有效性的了解 药品的价格。 建议的COMMERCAIL应用程序：不可用

DESCRIPTION: The overall goal of this research is to develop interactive software for performing sophisticated heterogeneity analysis of clinical trials involving multiple centers and/or multiple strata. In particular, the software will enable the user to explore how different strategies for combining treatment effects across strata (e.g. center, sex, race, disease severity, etc.) affect the resulting estimate of the overall treatment effect. By providing tools for systematically examining the magnitude and precision of multiple estimates of the overall treatment effect (based on the different combining strategies), the software will support the researcher in assessing the impact of any observed heterogeneity with regard to overall inference. This can also be viewed as a data-mining tool, enabling the researcher to interactively search for different possible structures in the data set. The ultimate benefit of successful development and deployment of this technology is improvement in health care by enabling researchers to better understand the nature of heterogeneity that may be encountered in clinical trials, thereby increasing the understanding of the overall safety and efficacy of drug products. PROPOSED COMMERCAIL APPLICATION: NOT AVAILABLE