A method for sterilization of human plasma and platelets

描述(由申请人提供)：本提案旨在开发一种方法来 延长保质期，增加人体血小板的安全性 灭菌方法。该方法提供了一种已知可以杀死一系列 体外微生物病原体，包括许多已知的细菌物种 污染浓缩血小板、真菌、寄生虫和病毒。致命的 试剂可以从不溶的聚合物中释放出来，这种聚合物可以加入到 组成收集袋的塑料。杀微生物剂分解了 迅速转化为正常的生理副产物，对 有耐心的。这种方法的成功开发将增加 血小板和血浆供应，并通过抑制微生物生长，增加 血小板的保质期。 这项工作的重点将是开发一种由 释放足够量致命剂的聚合物。备择 策略包括通过改变聚合物表面积来增加聚合物表面积 储存容器，这将允许释放足够的致命剂 功效。致命剂的抗菌谱将继续 在原型阶段之前和期间进行评估。对人的生理评估 致命剂对血小板的影响将被执行。原型 容器将在血库条件下进行测试。 建议的商业应用： 不可用

DESCRIPTION (provided by applicant): This proposal is to develop a method to prolong the shelf-life and increase the safety of human platelets with a unique method of sterilization. The method delivers an agent known to kill a range of microbial pathogens in vitro including many bacterial species known to contaminate platelet concentrates, fungi, parasites, and viruses. The lethal agent can be released from an insoluble polymer that can be incorporated into the plastic that comprises the collection bag. The microbicide breaks down rapidly to normal physiological by-products, presenting little danger to the patient. Successful development of this method will increase the safety of the platelet and plasma supply, and, by inhibiting microbial growth, increase the shelf-life of platelets. The focus of the effort will be to develop a storage container made from polymers that release sufficient quantities of the lethal agent. Alternative strategies include increasing the polymer surface area, via alterations in the storage container, that will allow release of sufficient lethal agent for efficacy. Antimicrobial spectra of the lethal agent will continue to be assessed before and during prototype stages. Physiological assessments of the effects of the lethal agent on platelets will be performed. Prototype containers will be tested under blood bank conditions. PROPOSED COMMERCIAL APPLICATION: Not Available