MOLECULAR GENETICS OF GESTATIONAL DIABETES MELLITUS--A GENETIC PREDISPOSITION

妊娠糖尿病的分子遗传学——一种遗传倾向

基本信息

  • 批准号:
    6304190
  • 负责人:
  • 金额:
    $ 2.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1999
  • 资助国家:
    美国
  • 起止时间:
    1999-12-01 至 2000-11-30
  • 项目状态:
    已结题

项目摘要

Women who develop gestational diabetes mellitus (GDM) progress to diabetes outside of pregnancy at a rate >5%/yr and account, therefore, for a sizable proportion of people with non-insulin dependent diabetes mellitus (NIDDM) whose mean age at diagnosis is relatively young. Moreover, impaired b-cell function is an important early predictor of the risk of developing DM among women with GDM. For these reasons, we have hypothesized that women with gestational diabetes mellitus (GDM) share a unique set of genetic characteristics apart from other presentations of NIDDM. The proposed studies are designed to create a bank of genomic DNA from and phenotypic information on several groups of participants, including (i)women with NIDDM subsequent to a history of GDM, (ii)women with a history of GDM who have normal glucose tolerance, (iii)women who do not have a history of GDM, (iv)individuals with typical, late-onset NIDDM (defined as onset after age 50), and (v)a reference group of individuals with normal glucose tolerance but who are at risk factor for late-onset NIDDM based upon a family history of a first degree relative with NIDDM, age over 50, or ethnicity (African-American, Hispanic, or Native American). This DNA and phenotypic information will be used to address our hypothesis in the present and future studies by examining the frequency of polymorphisms/mutations in previously identified genes that predispose to the development of maturity onset diabetes of the young (MODY), NIDDM, and obesity (a risk factor for NIDDM) in the different groups of participants and the association of those polymorphisms/mutations with alterations in the different phenotypic characteristics. These studies will be conducted using the about 1000 people who are currently undergoing oral glucose tolerance tests to determine their eligibility for participation in the Diabetes Prevention Program at Northwestern University Medical School and about 450 people who will be enrolled in another CRC-approved study ("Are Polymorphic Variants of the Leptin Receptor Gene Associated with Obesity and Gestational Diabetes Mellitus" - Protocol 597). The specific analysis that will be conducted in the proposed study will be to determine the prevalence rate of mutations in the transcription factor hepatocyte nuclear factor-1a in women with NIDDM subsequent to a history of GDM compared to the other four groups. Mutations in this gene result in maturity-onset diabetes of the young (MODY) and are, thus, associated with onset of diabetes at a young age.
患有妊娠期糖尿病(GDM)的妇女以-5%/年的速度进展到孕外糖尿病,因此,在确诊时平均年龄相对较小的非胰岛素依赖型糖尿病(NIDDM)患者中,有相当大的比例。此外,B细胞功能受损是妊娠期糖尿病妇女发生糖尿病风险的重要早期预测指标。由于这些原因,我们假设妊娠期糖尿病(GDM)妇女除了其他表现的NIDDM外,还有一组独特的遗传特征。建议的研究旨在创建几组参与者的基因组DNA和表型信息,包括(I)有妊娠期糖尿病病史的NIDDM妇女,(Ii)有正常糖耐量的GDM病史的妇女,(Iii)没有GDM病史的妇女,(Iv)典型的晚发性NIDDM患者(定义为50岁后发病),以及(V)具有正常糖耐量但处于晚发性NIDDM危险因素的参考组,这些个人基于50岁以上的NIDDM的一级亲属家族史,或种族(非裔美国人、西班牙裔或美洲原住民)。这些DNA和表型信息将被用来在目前和未来的研究中验证我们的假设,方法是检查在不同的参与者群体中,以前发现的易患青年成熟型糖尿病(MODY)、NIDDM和肥胖症(NIDDM的一个风险因素)的基因的多态/突变的频率,以及这些多态/突变与不同表型特征变化的关联。这些研究将使用目前正在接受口服葡萄糖耐量测试的约1000人进行,以确定他们是否有资格参加西北大学医学院的糖尿病预防计划,以及将参加另一项经CRC批准的研究的约450人(“瘦素受体基因的多态变体与肥胖和妊娠期糖尿病有关”-597议定书)。在拟议的研究中进行的具体分析将确定与其他四组相比,有妊娠期糖尿病病史的NIDDM妇女中转录因子肝细胞核因子-1a突变的患病率。该基因的突变导致青年成熟型糖尿病(MODY),因此与年轻时糖尿病的发病有关。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

William L Lowe其他文献

William L Lowe的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('William L Lowe', 18)}}的其他基金

Glycemic Profiles and Pregnancy Outcomes Study (GLOSS)
血糖曲线和妊娠结局研究 (GLOSS)
  • 批准号:
    10227745
  • 财政年份:
    2019
  • 资助金额:
    $ 2.05万
  • 项目类别:
Glycemic Profiles and Pregnancy Outcomes Study (GLOSS)
血糖曲线和妊娠结局研究 (GLOSS)
  • 批准号:
    10704001
  • 财政年份:
    2019
  • 资助金额:
    $ 2.05万
  • 项目类别:
Glycemic Profiles and Pregnancy Outcomes Study (GLOSS)
血糖曲线和妊娠结局研究 (GLOSS)
  • 批准号:
    10021649
  • 财政年份:
    2019
  • 资助金额:
    $ 2.05万
  • 项目类别:
Predicting Newborn and Childhood Adiposity: An Integrated Omics Approach
预测新生儿和儿童肥胖:综合组学方法
  • 批准号:
    10452488
  • 财政年份:
    2018
  • 资助金额:
    $ 2.05万
  • 项目类别:
Predicting Newborn and Childhood Adiposity: An Integrated Omics Approach
预测新生儿和儿童肥胖:综合组学方法
  • 批准号:
    10188519
  • 财政年份:
    2018
  • 资助金额:
    $ 2.05万
  • 项目类别:
Maternal Obesity and Gestational Diabetes: Impact on Metabolome
孕产妇肥胖和妊娠糖尿病:对代谢组的影响
  • 批准号:
    8638966
  • 财政年份:
    2013
  • 资助金额:
    $ 2.05万
  • 项目类别:
Genetics and Genomics of Maternal Glycemia During Pregnancy
孕期母亲血糖的遗传学和基因组学
  • 批准号:
    8726979
  • 财政年份:
    2013
  • 资助金额:
    $ 2.05万
  • 项目类别:
Maternal Obesity and Gestational Diabetes: Impact on Metabolome
孕产妇肥胖和妊娠糖尿病:对代谢组的影响
  • 批准号:
    8503043
  • 财政年份:
    2013
  • 资助金额:
    $ 2.05万
  • 项目类别:
Genetics and Genomics of Maternal Glycemia During Pregnancy
孕期母亲血糖的遗传学和基因组学
  • 批准号:
    8582891
  • 财政年份:
    2013
  • 资助金额:
    $ 2.05万
  • 项目类别:
Genetics and Evolution of Fetal Human Fat Accretion During Development
胎儿发育过程中脂肪积累的遗传学和进化
  • 批准号:
    8581302
  • 财政年份:
    2013
  • 资助金额:
    $ 2.05万
  • 项目类别:

相似海外基金

Sex and age difference in the immune response to viral myocarditis
病毒性心肌炎免疫反应的性别和年龄差异
  • 批准号:
    440151
  • 财政年份:
    2020
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Studentship Programs
An fMRI study of the effect of age difference on mind attribution
年龄差异对心理归因影响的功能磁共振成像研究
  • 批准号:
    19J12925
  • 财政年份:
    2019
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for JSPS Fellows
Effects of traumatic brain injury on hippocampal network activity: age difference
创伤性脑损伤对海马网络活动的影响:年龄差异
  • 批准号:
    8443632
  • 财政年份:
    2013
  • 资助金额:
    $ 2.05万
  • 项目类别:
Effects of traumatic brain injury on hippocampal network activity: age difference
创伤性脑损伤对海马网络活动的影响:年龄差异
  • 批准号:
    8669899
  • 财政年份:
    2013
  • 资助金额:
    $ 2.05万
  • 项目类别:
Subsurface water mass variations in the Kuroshio region inferred from 14C age difference of planktic foraminifers with different depth habitat
不同深度栖息地浮游有孔虫14C年龄差异推断黑潮地区地下水质量变化
  • 批准号:
    22654061
  • 财政年份:
    2010
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Age Difference of Spouses and Long-Term Care
配偶年龄差异与长期护理
  • 批准号:
    6400830
  • 财政年份:
    2001
  • 资助金额:
    $ 2.05万
  • 项目类别:
AGE DIFFERENCE IN ATTENTION--CONSEQUENCES FOR MEMORY
注意力的年龄差异——对记忆力的影响
  • 批准号:
    3453621
  • 财政年份:
    1992
  • 资助金额:
    $ 2.05万
  • 项目类别:
AGE DIFFERENCE IN ATTENTION--CONSEQUENCES FOR MEMORY
注意力的年龄差异——对记忆力的影响
  • 批准号:
    2051816
  • 财政年份:
    1992
  • 资助金额:
    $ 2.05万
  • 项目类别:
AGE DIFFERENCE IN ATTENTION--CONSEQUENCES FOR MEMORY
注意力的年龄差异——对记忆力的影响
  • 批准号:
    2051814
  • 财政年份:
    1992
  • 资助金额:
    $ 2.05万
  • 项目类别:
AGE DIFFERENCE IN ATTENTION--CONSEQUENCES FOR MEMORY
注意力的年龄差异——对记忆力的影响
  • 批准号:
    3453620
  • 财政年份:
    1992
  • 资助金额:
    $ 2.05万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了