课题基金 / 基金详情

DIRECT ADMIN /ADENOVIRIDAE VECTOR W/VEGF121/ CDNA TO LOWER ISCHEMIC LIMB

DIRECT ADMIN /ADENOVIRIDAE VECTOR W/VEGF121/ CDNA TO LOWER ISCHEMIC LIMB
直接管理/腺病毒载体 W/VEGF121/ CDNA 至下肢缺血
批准号：
6304094
负责人：
RONALD G CRYSTAL
金额：
$7.95万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6304094
关键词：
Adenoviridae blood disorder chemotherapy blood vessel occlusion blood vessels clinical research clinical trials drug administration routes gene therapy human subject human therapy evaluation ischemia limbs transfection /expression vector vascular endothelial growth factors

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中文摘要
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英文摘要
This protocol is designed to determine the safety/toxicity and biologic efficacy of direct administration of the AdGVVEGF121.10 vector to the lower limb of individuals with peripheral vascular disease. At the conclusion of the study, in addition to the objective described above, the investigators will demonstrate whether direct administration of AdGVVEGF121.10 to the lower limb will induce growth of collateral blood vessels, improve blood flow in the region of ischemia.
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