CHEMOPREVENTION WITH RODENT MODELS OF HEAD & NECK TUMORS

头颈部肿瘤是比较常见的上皮性肿瘤 在人们身上。头部和颈部的肿瘤似乎提供了一个特别的 自手术后的临床研究的呼吁模式 干预：肿瘤局部复发率相对较低 很高。事实上，此前已有研究表明，维甲酸可以 显著改变头部肿瘤的复发率和 脖子。化学预防处在这方面的初步尝试 具体区域需要使用DMBA仓鼠的面颊袋模型。 总的来说，我们发现该模型对各种 化学保护剂。因此，我们希望研究另一种模式。 第一种是大鼠舌癌诱发模型。 使用致癌物质4NQO。正如Gerson口腔损害在 4-NQO产生的大鼠与人类的病变相似，因为许多 溃烂和内生性舌部病变。该计划的目标是 拟议的研究将调查一系列四种化合物 在4NQO模型中进行化学预防活动，并执行 转基因模型中单剂作用的初步研究。

Tumors of the head and neck are relatively common epithelial tumors in people. Tumors of the head and neck appear to offer a particularly appealing model for clinical studies since following surgical intervention the rate of local recurrence of tumors is relatively high. In fact it has previously been shown that retinoids can significantly alter the rate of recurrence of tumors of the head and neck. The initial attempts of the Chemoprevention Branch in this specific area entailed the use of the DMBA hamster cheek pouch model. In general we found this model to be unresponsive to a variety of chemopreventives. We wish therefore to examine an alternative model. The first is a model for inducing tumors of the tongue in rats employing the carcinogen 4NQO. As reviewed by Gerson oral lesions in rats produced by 4-NQO are similar to human lesions since manyare ulcerated and endophytic tongue lesions. The objective of the proposed studies will be to investigate a series of four compounds for chemopreventive activity in the 4NQO model and to perform preliminary studies with a single agent in the transgenic model.