MUSCLE ATROPHY: ISOMETRIC & ISOKINETIC TESTING OF ANKLE PLANTAR FLEXION

骨关节炎（OA）是一种软骨退行性疾病， 伴随着剧烈的疼痛和无法动弹 OA的早期发现 是有效治疗所必需的。 初 在OA的阶段，存在蛋白聚糖（PG）分子的损失， 关节软骨 最近，我们已经证明了 通过定量钠间接测量软骨中的PG损失， 体内和体外关节软骨的23 Na MRI。 准确 定量必须考虑软骨内钠， 以及软骨外滑液。 以确定 这两个来源的23 Na MRI信号的相对贡献，我们 对放置在胫骨平台上的髌骨标本进行T1和T2加权23Na MRI， 生理浓度盐水浴。 初步结果 这表明有可能从滑膜中去除贡献， 通过明智地选择成像参数， 进一步 体外和体内定量正在进行中。

Osteoarthritis (OA) is a degenerative disease of cartilage and is associated with severe pain and immobilization. Early detection of OA is necessary for efficient therapeutic intervention. In the early stage of OA, there is a loss of proteoglycan (PG) molecules from articular cartilage. Recently, we have shown the feasibility of indirectly measuring PG loss in cartilage by quantitation of sodium by 23Na MRI of articular cartilage in-vivo and in-vitro. An accurate quantitation must account for both the intra-cartilage sodium, which is of interest, and the extra-cartilage synovial fluid. To determine the relative contributions of these two sources of 23Na MRI signal, we performed T1 and T2 weighted 23Na MRI of patella specimen placed in a bath of physiologic concentration saline. Preliminary results indicate that it is possible to remove the contribution from synovial fluid by judicious selection of imaging parameters. Further quantitation in vitro and in vivo is in progress.