FINE MAPPING OF CROHNS DISEASE LOCUS ON CHROMOSOME 16:INFLAMMATORY BOWEL DISEASE

脑血管（CV）疾病是第三大死亡原因 在美国，大约四分之一的CV死亡是由于破裂 颅内动脉瘤（IA）。 在破裂后幸存的人中， 一半的人留下了神经缺陷 选择性手术和 破裂前的治疗对于预防发病非常有效 and mortality. 早期识别易患IA的个体 因此，将大大提高我们防止最严重 结果。 49例患病同胞的基因组扫描初步分析 pairs已经完成。 多个候选区域（其中一个具有lod 评分> 2.5）有牵连。 我们目前正在对 在原始49对上的这些候选区域中的附加标记 和一组额外的配对，试图确认与一个 或更多的这些地区。

Cerebrovascular (CV) disease is the third leading cause of death in the U.S. and about one-quarter of the CV deaths are due to ruptured intracranial aneurysms (IA). Of those that survive rupture, more than half are left with neurological deficits. Elective surgery and treatment prior to rupture are very effective in preventing morbidity and mortality. Early identification of individuals susceptible to IA would therefore greatly enhance our ability to prevent most serious outcomes. Preliminary analysis of a genome scan of 49 affected sib pairs has been completed. Several candidate regions (one with lod score > 2.5) have been implicated. We are currently genotyping additional markers in these candidate regions on the original 49 pairs and an additional set of pairs in an attempt to confirm linkage to one or more of these regions.