elucidating the role of Tumour Necrosis Factor Receptor 1 (TNFR1) in regulating acute inflammatory responses of leukocyte trafficking and vascular per

阐明肿瘤坏死因子受体 1 (TNFR1) 在调节白细胞运输和血管内皮细胞急性炎症反应中的作用

• 批准号: 1797224
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1797224
• 关键词: elucidating; role; Tumour; Necrosis; Factor

The specific objective of the PhD project will be to utilise novel pharmacological reagents generated by GSK to dissect the molecular contribution of TNFR1-dependent signalling in regulation of neutrophil-vessel wall dynamics and vascular leakage in models of vascular and tissue injury. The project will involve use of numerous in vivo experimental models of inflammation in conjunction with biochemical and cellular assays. In addition the project will employ cutting edge imaging modalities, including confocal intravital microscopy for real-time tracking of microvascular responses, a specialised technique for which the group is internationally respected.

博士项目的具体目标将是利用GSK产生的新型药理学试剂来剖析TNFR1依赖性信号传导在血管和组织损伤模型中调节嗜中性粒细胞血管壁动力学和血管渗漏的分子贡献。该项目将涉及使用许多体内实验模型的炎症结合生化和细胞分析。此外，该项目还将采用最先进的成像方式，包括用于实时跟踪微血管反应的共聚焦活体显微镜，这是一种国际上备受推崇的专业技术。

项目成果

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs.

局部微血管渗漏促进活化的中性粒细胞向远端器官的运输。

• DOI: 10.1172/jci133661
• 发表时间: 2020
• 期刊: The Journal of clinical investigation
• 作者: Owen-Woods C