2002 Myogenic Centennial Conference

描述（由申请人提供）：肌生成百年会议将是 2002年9月11日至15日在佛蒙特州伯灵顿举行。从历史 从这个角度来看，这次会议是为了纪念建国100周年 威廉·贝利斯爵士1902年发表的经典论文首次描述了 血管肌源性反应是一种生理现象， 控制基础血管张力、外周阻力、血压和血液 流量自动调节最简单的定义是血管的内在能力， 平滑肌响应血管内压力产生力， 这一基本属性的生理重要性-这一直是 在动脉、小动脉、静脉和血管中的描述是公认的。作为 这样的生肌行为对血管生理学具有广泛的影响（例如， 发育和年龄相关变化、性别差异、怀孕）， 病理学（动脉粥样硬化、糖尿病、高血压、先兆子痫、中风）和 一些研究所，如NINDS，NIGMS和NHLBI，可能会感兴趣。的 会议的形式在研究计划中有详细说明，并将包括一个 开幕式演讲，24名知名科学家的口头报告， 有助于突出关于关键问题现有知识， 会议将平行的口头会议的主题，并探讨一些 更有争议的问题，并允许年轻的研究人员提出， 阐述他们的工作，两个研讨会旨在激发讨论， 最有趣的新观察，探索最令人困惑的， 与血管肌原性行为相关的挑衅性问题。会议将 吸引100-120名与会者，采用旨在鼓励积极参与的形式， 参与，并包括在小组讨论和 个性化设置。已经建立了一个程序， 在会议上将被用作确定争议领域的基础 和未来的研究方向，并产生问题， 在研讨会上发言。主要目标是带来历史和 在一个独特的和前瞻性的会议上， 重点是：（1）更新和整合我们对血管的认识， 根据分子遗传学和成像的最新进展， 技术，以及（2）促进未来的合作和沟通， 年轻的研究人员和成熟的科学家。

DESCRIPTION (provided by applicant): The Myogenic Centennial Conference will be held in Burlington, Vermont on September 11-15, 2002. From a historical standpoint, this meeting will commemorate the 100th anniversary of the publication of Sir William Bayliss' classic 1902 paper that first described the vascular myogenic response, a physiologic phenomenon that is integral to the control of basal vascular tone, peripheral resistance, blood pressure and blood flow autoregulation. Defined most simply as the intrinsic ability of vascular smooth muscle to generate force in response to intravascular pressure, the physiological importance of this fundamental property - which has been described in arteries, arterioles, veins and lymphatics is well-established. As such, myogenic behavior has a broad impact on vascular physiology (e.g. developmental and age-related changes, gender differences, pregnancy) and pathology (atherosclerosis, diabetes, hypertension, preeclampsia, stroke) and would be of interest to several institutes, e.g. NINDS, NIGMS, and NHLBI. The format of the conference is detailed in the Research Plan, and will include an opening lecture, 24 oral presentations by established scientists that will serve to highlight current knowledge on key issues, two poster discussion sessions that will parallel the themes of the oral sessions and explore some of the more controversial issues and allow younger investigators to present and articulate their work, and two workshops designed to stimulate discussion about the most intriguing new observations and explore the most puzzling and provocative issues relevant to vascular myogenic behavior. The meeting will attract 100-120 attendees, utilizes a format designed to encourage active participation, and includes ample time for discussion in both the group and individual settings. A process has been set up by which information presented at the meeting will be used as a substrate for identifying areas of controversy and future directions in research, and for generating questions that will be addressed in the workshops. The principal goals are to bring historical and physiological antecedents together in a unique and forward-looking conference focused on: (1) updating and integrating our knowledge about the vascular myogenic behavior in light of recent advances in molecular genetics and imaging technology, and (2) catalyzing future collaboration and communication between younger investigators and established scientists.