Self-assembling polymers and peptides for hydroxyapatite mineralisation

用于羟基磷灰石矿化的自组装聚合物和肽

• 批准号: 1799702
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1799702
• 关键词: Self; assembling; polymers; peptides; hydroxyapatite

The aim of the project is to design self-assembling polymers and small molecules that control the nucleation and growth of hydroxyapatite crystals in the oral environment. We will develop smart block copolymers with pH-responsive self-assembly and peptide-inspired polymers, both of which self-assemble into morphologies like hydrogels, micellar, lamellar and worm-like micelles. The polymers will be functionalised with acidic moieties so as to induce the crystallisation of calcium phosphate in the form of hydroxyapatite. We expect that the morphology of the self-assembled structures will help direct the morphology of the nascent hydroxyapatite crystals, leading to mineralised structures that mimic those of hydroxyapatite in tooth enamel.This project will be a collaboration between Dr M Shaver (PI) and Dr F Nudelman (Co-supervisor), and Dr C Fowler (GSK Healthcare).The project fits into the EPSRC remit including the theme of Healthcare technology, research area of Biomaterials and tissue engineering: "Research into biomedical materials with novel chemical, physical or mechanical properties or use of materials in a range of medical applications and interventions including regenerative medicine".

该项目的目的是设计自组装聚合物和小分子，以控制口腔环境中羟基磷灰石晶体的成核和生长。我们将开发具有pH响应性自组装和肽启发聚合物的智能嵌段共聚物，这两种聚合物均自组装成水凝胶，胶束，层状和蠕虫状胶束等形态。聚合物将用酸性部分官能化，以诱导磷酸钙以羟基磷灰石形式结晶。我们期望这种自组装结构的形态将有助于指导新生羟基磷灰石晶体的形态，从而导致模仿牙釉质中羟基磷灰石的矿化结构。（联合主管）和C福勒博士（GSK Healthcare）。该项目符合EPSRC的职权范围，包括医疗保健技术主题，生物材料和组织工程研究领域：“研究具有新的化学，物理或机械特性的生物医学材料，或在一系列医疗应用和干预（包括再生医学）中使用材料”。