Conference on Wiring and Plasticity of Nervous Systems

描述(申请人提供)：细胞生物学家最近绘制了 信号通路(小GTP酶到WASP/SCAR蛋白到Arp2/3复合体) 控制肌动蛋白细丝的组装，使其向前推进 可移动的细胞。神经生物学家独立地确定了关键的血浆 引导细胞运动的可溶性和基质分子的膜受体 在神经的硬连接过程中，神经元生长锥体到达它们的目标 系统，这个过程产生了大约一百万英里的神经元 在人脑中的过程！在整个生命过程中，突触连接被重塑 响应似乎也依赖于肌动蛋白进程的活动 集合。尽管细胞生物学家致力于细胞运动机制的研究 致力于大脑发育和可塑性的神经科学家 在调查相同的过程中，沟通一直很少。一 神经生物学家评论说：“这些群体很少出现在 现在是时候举行一次研讨会了，它将带来 科学家们共同研究基于肌动蛋白的运动性和发育 神经系统。我们相信，将出现互惠互利的见解 从相互了解中学习工作。

DESCRIPTION (provided by applicant): Cell biologists recently mapped the signaling pathways (small GTPases to WASP/Scar proteins to Arp2/3 complex) that control the assembly of actin filaments that drives forward the leading edge of motile cells. Independently, neurobiologists have identified key plasma membrane receptors for soluble and matrix molecules that guide the motility of neuronal growth cones to their targets during the hard wiring of the nervous system, a process that produces approximately one million miles of neuronal process in the human brain! Throughout life, synaptic connections are remodeled in response to activity by processes that also appear to depend on actin assembly. Although cell biologists working on mechanisms of cellular motility and neuroscientists working on brain development and plasticity are investigating on the same process, communications have been minimal. One neurobiologist commented that "these groups have rarely if ever been seen in the same room." The time is now opportune for a symposium that will bring together scientists working on both actin-based motility and development of nervous systems. We are confident that mutually beneficial insights will emerge from learning about each others work.