PLANT STANOL ESTERS ON USUAL DIET VS NCEP STEP 1 DIET ON LIPIDS & LIP

常规饮食中的植物甾烷醇酯与 NCEP 第 1 步饮食中的脂质

• 批准号: 6421255
• 负责人: PETER JONES
• 金额: $ 15.58万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6421255
• 关键词: antihypercholesterolemic agent; blood lipoprotein metabolism; clinical research; diet; diet therapy; high density lipoproteins; human subject; human therapy evaluation; lipid metabolism; low density lipoprotein; nutrition related tag; sterol ester; very low density lipoprotein

Phytosterols are naturally occurring plant sterols in which the C5-C6 bond is saturated. Thus, while sitostanol bears a double bond at this position, sitostanol has a single bond. Sitostanol is almost completely unabsorbable by the intestine and also reduces the absorption of cholesterol. The cholesterol-lowering effect of sitostanol is increased by converting it to fatty acid esters. In studies conducted in Finnish hypercholesterolemic subjects, plant stanol esters (PSE) have shown decreases in total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) of 6 to 11% and 9 to 14%, respectively. The diet of Finnish research subjects was higher in total fat, saturated fat, and cholesterol than the typical American diet. It is important to determine if a diet lower in total and saturated fat, the Step I Diet, and PSE together will result in LDL-C lowering that exceeds either treatment alone. The purpose of this randomized controlled 6-week study is to: 1) determine if there are differences among four treatment groups (usual diet, usual diet + PSE, Step I Diet, Step I Diet + PSE), 2) to quantify changes that may occur in lipoprotein composition of very low density lipoprotein (VLDL), LDL-C, high density lipoprotein (HDL), and appropriate subfractions of subjects incorporating PSE into their usual diets or the Step I Diet, and 3) to determine the time dependence of changes in level of lipids and lipoproteins.

植物甾醇是天然存在的植物甾醇，其中C5-C6键饱和。 因此，虽然谷甾烷醇在该位置具有双键，但谷甾烷醇具有单键。 谷甾烷醇几乎完全不能被肠道吸收，也会减少胆固醇的吸收。 谷甾烷醇的降胆固醇作用通过将其转化为脂肪酸酯而增加。 在芬兰高胆固醇血症受试者中进行的研究中，植物甾烷醇酯（PSE）显示总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）分别降低6至11%和9至14%。 芬兰研究对象的饮食中总脂肪、饱和脂肪和胆固醇含量高于典型的美国饮食。 重要的是要确定总脂肪和饱和脂肪含量较低的饮食、第一步饮食和PSE一起是否会导致LDL-C降低超过单独的治疗。 这项为期6周的随机对照研究的目的是：1）确定四个治疗组之间是否存在差异（普通饮食、普通饮食+ PSE、步骤I饮食、步骤I饮食+ PSE），2）定量极低密度脂蛋白（VLDL）、LDL-C、高密度脂蛋白（HDL）的脂蛋白组成中可能发生的变化，以及将PSE掺入其常规饮食或步骤I饮食中的受试者的适当亚部分，和3）确定脂质和脂蛋白水平变化的时间依赖性。