The role of hTRPA1 in Pain Sensation

hTRPA1 在痛觉中的作用

• 批准号: 1801761
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1801761
• 关键词: role; hTRPA1; Pain; Sensation

Long lasting and recurrent pain is a major health problem worldwide, especially in aging populations. Developing new and effective treatments for pain is hampered by a lack of understanding of the processes that give rise to the feeling of pain. Furthermore, it is not understood hy certain chemicals (such as riot control agents) cause pain. The role of this project is to ascertain the exact mechanisms by which the feeling of pain originates from activation of the protein human TRPA1 (hTRPA1) which will give insights into how to accelerate the development of treatments for pain and also how to more effectively protect humans from the actions of irritant chemicals. Through furthering the understanding of pain and its fundamental mechanisms, this project will address the BBSRC priority areas of bioscience for human health and world-class underpinning bioscience. IBB, ENWW

长期和复发性疼痛是世界范围内的一个主要健康问题，特别是在老龄化人口中。由于缺乏对产生疼痛感觉的过程的理解，开发新的有效的疼痛治疗方法受到阻碍。此外，人们还不明白为什么某些化学物质（如防暴剂）会引起疼痛。这个项目的作用是确定疼痛的感觉源自人类TRPA1蛋白（hTRPA1）激活的确切机制，这将为如何加速疼痛治疗的发展以及如何更有效地保护人类免受刺激性化学物质的影响提供见解。通过进一步了解疼痛及其基本机制，该项目将解决BBSRC人类健康生物科学和世界级基础生物科学的优先领域。IBB, ENWW