The role of hTRPA1 in Pain Sensation

持久和反复的疼痛是世界范围内的一个主要健康问题，特别是在老龄化人口中。由于缺乏对引起疼痛感觉的过程的了解，开发新的有效的疼痛治疗方法受到阻碍。此外，人们不知道某些化学物质(如防暴剂)会引起疼痛。这个项目的作用是确定人类TRPA1(HTRPA1)蛋白激活产生痛感的确切机制，这将为如何加快疼痛治疗的发展以及如何更有效地保护人类免受刺激性化学物质的作用提供见解。通过进一步了解疼痛及其基本机制，该项目将解决BBSRC为人类健康和世界级生物科学奠定基础的生物科学的优先领域。伊布，西南部

Long lasting and recurrent pain is a major health problem worldwide, especially in aging populations. Developing new and effective treatments for pain is hampered by a lack of understanding of the processes that give rise to the feeling of pain. Furthermore, it is not understood hy certain chemicals (such as riot control agents) cause pain. The role of this project is to ascertain the exact mechanisms by which the feeling of pain originates from activation of the protein human TRPA1 (hTRPA1) which will give insights into how to accelerate the development of treatments for pain and also how to more effectively protect humans from the actions of irritant chemicals. Through furthering the understanding of pain and its fundamental mechanisms, this project will address the BBSRC priority areas of bioscience for human health and world-class underpinning bioscience. IBB, ENWW