Tackling TB in cattle: identifying inhibitors of cell wall biosynthesis enzymes from Mycobacterium bovis, the causitive agent of bovine TB.

应对牛结核病：鉴定牛分枝杆菌（牛结核病的病原体）细胞壁生物合成酶的抑制剂。

• 批准号: 1803173
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1803173
• 关键词: Tackling; TB; cattle; identifying; inhibitors

Synthesis of rationally designed inhibitors of enzymes essential to the biosynthesis of the cell wall of Mycobacterium bovis, the causative agent of tuberculosis in cattle for further evaluation in assays against the isolated enzyme and whole Mycobacterium bovis. The project will involve some computational docking of molecules into the enzyme active site together with the synthesis of the compounds.Whilst this rotation project is self-contained, one option would be to follow-on from this with the project led by Dr De Matteis in which the activity of the compounds synthesized could be determined.

牛分枝杆菌细胞壁生物合成所必需的酶的合理设计的抑制剂的合成，牛结核病的病原体，用于针对分离的酶和完整的牛分枝杆菌的测定中的进一步评价。该项目将涉及一些分子与酶活性位点的计算对接以及化合物的合成。虽然这个旋转项目是独立的，但一个选择是继续由De Matteis博士领导的项目，其中可以确定合成化合物的活性。