Development and Strategic Application of Metal-catalysed Methods in the Synthesis of Novel Steroidal Natural Products

该方案将在有机钯催化和有机钴化学方面建立新的和正在开发的技术和战略，以便能够以化学选择性和立体选择性的方式快速获得多环前体和最终产品。基于钯的不对称方法将与要求苛刻的底物化合物一起建立，以提供获得有价值的多环产品的途径。此外，加强胚胎催化的Pauson-Khandd系统，结合无气味的硫化物促进方案，将导致在钴介导的环化领域内具有重大价值的真正的方法学进步。这些技术将结合在一起，以获得制备要求严格的新型甾体化合物。这将包括姬松茸家族的天然产品；基于来自同一真菌来源的替代化合物，本方案所针对的分子物种有可能展示一系列生物活性。

This programme will establish new and developing techniques and strategies in both organopalladium catalysis and organocobalt chemistry to allow rapid access to polycyclic precursors and final products in both a chemoselective and stereoselective fashion. Asymmetric palladium-based methods will be established with demanding substrate compounds to provide access to valuable polycyclic products. Furthermore, enhancement of embryonic catalytic Pauson-Khand systems, married with odour-free sulfide promotion protocols, will lead to a genuine methodological advancement of significant value within the arena of cobalt-mediated cyclisations. These techniques will be combined in order to access preparatively demanding novel steroidal compounds. This will include natural products from the Agaricus blazei family; based on alternative compounds from the same fungal source, the molecular species targeted within this programme have the potential to display a spectrum of biological activity.