Development and Strategic Application of Metal-catalysed Methods in the Synthesis of Novel Steroidal Natural Products

金属催化方法在新型甾体天然产物合成中的发展和战略应用

• 批准号: 1803771
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1803771
• 关键词: Development; Strategic; Application; Metal; catalysed

This programme will establish new and developing techniques and strategies in both organopalladium catalysis and organocobalt chemistry to allow rapid access to polycyclic precursors and final products in both a chemoselective and stereoselective fashion. Asymmetric palladium-based methods will be established with demanding substrate compounds to provide access to valuable polycyclic products. Furthermore, enhancement of embryonic catalytic Pauson-Khand systems, married with odour-free sulfide promotion protocols, will lead to a genuine methodological advancement of significant value within the arena of cobalt-mediated cyclisations. These techniques will be combined in order to access preparatively demanding novel steroidal compounds. This will include natural products from the Agaricus blazei family; based on alternative compounds from the same fungal source, the molecular species targeted within this programme have the potential to display a spectrum of biological activity.

该方案将在有机钯催化和有机钴化学方面建立新的和发展中的技术和战略，以便以化学选择性和立体选择性的方式快速获得多环前体和最终产品。不对称钯基方法将与苛刻的底物化合物建立，以提供有价值的多环产品。此外，胚胎催化Pauson-Khand系统的增强，与无气味硫化物促进协议相结合，将在钴介导的环化领域带来具有重要价值的真正的方法进步。这些技术将结合起来，以获得制备要求高的新型甾体化合物。这将包括来自姬蘑菇家族的天然产品；基于来自同一真菌来源的替代化合物，该计划所针对的分子物种具有显示一系列生物活性的潜力。