How the Vaccinia virus protein C6, inhibits IFN-gamma signalling

痘苗病毒蛋白 C6 如何抑制 IFN-γ 信号传导

• 批准号: 1804930
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1804930
• 关键词: How; Vaccinia; virus; protein; C6

Theme: World-Class Underpinning BioscienceThe Vaccinia virus protein C6 has been shown to inhibit the induction of IFN-gamma, a critical cytokine of the immune response. This project would sort to understand the molecular mechanism by which C6 can inhibit this pathway, both improving our understanding of virus/host interactions and fundamental cell biology processes. ENWW:- Project has the potential to utilise high throughput proteomics/genomics though which I can apply bioinformatics analysis to better understand the changes in gene expression/ virus host interactions during virus infection.

主题：世界级支撑生物科学痘苗病毒蛋白C6已被证明可抑制干扰素-γ的诱导，干扰素-γ是免疫反应的关键细胞因子。这个项目将有助于了解C6抑制这一途径的分子机制，从而提高我们对病毒/宿主相互作用和基本细胞生物学过程的理解。ENWW：-项目有可能利用高通量蛋白质组学/基因组学，通过这种组学，我可以应用生物信息学分析来更好地了解病毒感染期间基因表达/病毒宿主相互作用的变化。

项目成果

A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses

抑制致病性痘病毒和副粘病毒中保守的 STAT1 信号传导的策略

• DOI: 10.17863/cam.86923
• 发表时间: 2022
• 作者: Talbot-Cooper C

Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling.

• DOI: 10.1016/j.chom.2022.01.014
• 发表时间: 2022-03-09
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: Talbot-Cooper C;Pantelejevs T;Shannon JP;Cherry CR;Au MT;Hyvönen M;Hickman HD;Smith GL
• 通讯作者: Smith GL