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Animal Model of Ethanol-Induced Cardiomyopathy

Animal Model of Ethanol-Induced Cardiomyopathy
乙醇诱发的心肌病动物模型
批准号：
6485340
负责人：
Judith K Gwathmey
金额：
$27.93万
依托单位：
GWATHMEY, INC.
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
项目状态：
已结题
起止时间：
2002-09-25 至 2003-08-31
来源：
https://reporter.nih.gov/project-details/6485340
关键词：
alcoholism /alcohol abuse cardiotoxin chickens disease /disorder model ethanol heart failure model design /development myocardium disorder

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英文摘要
DESCRIPTION (provided by applicant): This proposal was prepared in response to the National Institute on Alcohol Abuse and Alcoholism request for proposals to develop new models that more closely mimic human disease. Studies on the effects of ethanol on myocardial contractility have been ongoing for over the last twenty years. Studies in animals chronically administered ethanol and models of ethanol-induced disease studied previously, as well as currently, do not compare well to the human condition. Reproducible ethanol-induced cardiomyopathy has been difficult to produce in animals. This has hindered experimental studies of this disease. No one to date has produced congestive cardiomyopathy or heart failure in an animal model of chronic ethanol intake.
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Ferroptosis in the Heart: Iron Calcium Crosstalk and Compartmentalization
  • 批准号：
    10364032
  • 项目类别：
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  • 财政年份：
    2021
  • 负责人：
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  • 依托单位：
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Ferroptosis in the Heart: Iron Calcium Crosstalk and Compartmentalization
BIOMEDICAL (APPLIED/EXPLORATORY)
  • 批准号：
    7934246
  • 项目类别：
  • 资助金额：
    $27.91万
  • 财政年份：
    2009
  • 负责人：
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  • 依托单位：
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Molecular Medicine Approaches to the Treatment of Vascular Disease
  • 批准号：
    7395205
  • 项目类别：
  • 资助金额：
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  • 财政年份：
    2008
  • 负责人：
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  • 依托单位：
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