Tissue-Specific Antioxidant Antimutagenesis

描述：(申请人提供)抗氧化剂对人体的潜在影响 近年来，衰老和退行性疾病得到了广泛的认识， 每年在巨糖抗氧化剂补充剂上花费数十亿美元。这个 现代衰老自由基理论假定 抗氧化剂/促氧化剂平衡导致氧化应激增加， 细胞功能失调和衰老。在这个理论的背景下， 抗氧化剂可以影响主要的“内在”衰老过程以及 几个与年龄相关的继发性病理过程。几个 流行病学和临床研究揭示了饮食的潜在作用 与年龄相关的自身免疫性疾病中的抗氧化剂，以及风险的降低 癌症的发病率和死亡率。蓝色转基因大鼠的突变 检测系统允许氧化应激，突变， 以及致癌性，以一种以前不可能的方式进行检查。大公司 蓝色系统将被用来测量饮食中抗氧化剂对 突变频率和模式与正常条件下的肿瘤发生 并增加内源性氧化应激。这一结果可能会为我们提供对 组织特异性氧化应激的性质和程度 为未来的研究奠定基础，以修改发生或进展的 肿瘤发生学。这一结果将对我们的理解产生影响 人类自发性体细胞突变及其最大值的确定 维生素E、C和β-胡萝卜素补充剂的抗突变作用 或者在鸡尾酒里。

DESCRIPTION: (provided by applicant) The potential impact of antioxidants on aging and degenerative diseases has been widely recognized in recent years and billions of dollars are spent annually on megadose antioxidant supplements. The modem free radical theory of aging postulates a shift in the antioxidant/pro-oxidant balance that leads to increased oxidative stress, dysregulation of cellular function, and aging. In the context of this theory, antioxidants can influence the primary "intrinsic" aging process as well as several secondary age-associated pathological processes. Several epidemiological and clinical studies have revealed potential roles for dietary antioxidants in age-associated autoimmune diseases, and the reduction of risk of morbidity and mortality from cancer. The Big Blue transgenic mouse mutation detection system allows the relationship between oxidative stress, mutagenesis, and carcinogenesis to be examined in a manner not previously possible. The Big Blue system will be utilized to measure the effects of dietary antioxidants on mutation frequency and pattern, and tumorigenesis under conditions of normal and elevated endogenous oxidative stress. The results may provide insight into the nature and extent of tissue-specific oxidative stress and lay the foundation for future studies to modify the incidence or progression of tumorigenesis. The results will have implications for our understanding spontaneous somatic mutation in humans and for defining the maximal antimutagenic effect of vitamin E, C and beta-carotene supplements separately or in cocktails.