ESTROGEN IN THE PREVENTION OF ATHEROSCLEROSIS TRIAL
ESTROGEN IN THE PREVENTION OF ATHEROSCLEROSIS TRIAL
批准号:
6509941
负责人:
Howard Neil Hodis
金额:
$45.42万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-01 至 2005-03-31
关键词:
atherosclerosis blood lipoprotein metabolism carbohydrate metabolism cardiovascular disorder prevention carotid artery clinical trials estrogens female fibrinolysis homocysteine hormone therapy human middle age (35-64) human old age (65+) human subject human therapy evaluation information systems lipid transport low density lipoprotein nitric oxide oxidation pathologic process patient oriented research placebos postmenopause women's health
中文摘要
描述(申请人的逐字描述):现有证据表明
英文摘要
DESCRIPTION (the applicant's description verbatim): Current evidence indicates
that unopposed estrogen replacement therapy (ERT) reduces cardiovascular
morbidity and mortality. In part, the cardioprotective effects of oral estrogen
are believed to be due to a) alteration of lipid transport pattern, b)
ERT-induced effects on lipid transport not totally reflected by measurement of
cholesterol and triglyceride levels, and/or c) non-lipid effects of ERT.
Although previous studies have shown that ERT has beneficial effects on
presumptive risk factors for cardiovascular disease (CVD) in postmenopausal
women, these studies have yielded limited information concerning these effects
directly on the actual atherosclerosis process because of the absence of
arterial imaging endpoints. In short, the univariate associations of ERT on
lipid and non-lipid endpoints, as well as the multivariate associations of ERT,
lipid and non-lipid endpoints on the atherosclerosis process in postmenopausal
women are poorly understood. We plan to address these issues with a recently
completed randomized, double-blind, placebo-controlled, carotid artery
ultrasonographic ERT trial in 221 healthy postmenopausal women 46 to 80 years
old without CVD symptoms (primary prevention). The Estrogen in the Prevention
of Atherosclerosis Trial (EPAT) provides a unique opportunity to evaluate the
association of lipid and non-lipid factors of unopposed ERT-mediated reduction
in the progression of subclinical atherosclerosis in healthy postmenopausal
women under conditions which eliminate self-selection and differential
interaction with the medical care system. In EPAT, unopposed ERT significantly
reduced the rate of change of carotid artery intima-media thickness (IMT) as
compare to placebo. By determining the effects of ERT on putative CVD risk
factors in postmenopausal women and linking these effects to arterial wall
change in carotid IMT, we will be able to study the effects of ERT directly on
the progression of subclinical atherosclerosis. Specifically, we plan to study
the effects of ERT on regulation of lipoprotein metabolism with standard lipid
measures as well as with measures beyond the traditional cholesterol and
triglyceride lipid measurements, the thrombotic/thrombolytic system, LDL
oxidation, and carbohydrate, homocysteine and nitric oxide metabolism, and a
variety of clinical measures. Because the clinical trial phase of EPAT is
completed, a very large and rich database is available at considerable savings.
Since 90 percent of coronary deaths of women occur after menopause, elucidating
the effects by which unopposed ERT reduces the progression of subclinical
atherosclerosis in healthy postmenopausal women has important public health
implications for the prevention of CVD in postmenopausal women.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Atherosclerosis Intervention with Novel Tissue Selective Estrogen Complex Therapy
-
批准号:10250300
-
项目类别:
-
资助金额:$283.79万
-
财政年份:2019
-
负责人:Howard Neil Hodis
-
依托单位:
Atherosclerosis Intervention with Novel Tissue Selective Estrogen Complex Therapy
-
批准号:10456132
-
项目类别:
-
资助金额:$276.91万
-
财政年份:2019
-
负责人:Howard Neil Hodis
-
依托单位:
MECHANISMS UNDERLYING THE AGE-RELATED ATHEROPROTECTIVE EFFECTS OF HORMONE THERAPY
-
批准号:10188371
-
项目类别:
-
资助金额:$72.4万
-
财政年份:2018
-
负责人:Howard Neil Hodis
-
依托单位:
MECHANISMS UNDERLYING THE AGE-RELATED ATHEROPROTECTIVE EFFECTS OF HORMONE THERAPY
-
批准号:10417054
-
项目类别:
-
资助金额:$72.4万
-
财政年份:2018
-
负责人:Howard Neil Hodis
-
依托单位:
MECHANISMS UNDERLYING THE AGE-RELATED ATHEROPROTECTIVE EFFECTS OF HORMONE THERAPY
-
批准号:9752440
-
项目类别:
-
资助金额:$72.4万
-
财政年份:2018
-
负责人:Howard Neil Hodis
-
依托单位:
Vitamin D Intervention and Atherosclerosis Progression in African American Women
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批准号:8669138
-
项目类别:
-
资助金额:$37.27万
-
财政年份:2012
-
负责人:Howard Neil Hodis
-
依托单位:
Vitamin D Intervention and Atherosclerosis Progression in African American Women
-
批准号:8534252
-
项目类别:
-
资助金额:$35.89万
-
财政年份:2012
-
负责人:Howard Neil Hodis
-
依托单位:
Vitamin D Intervention and Atherosclerosis Progression in African American Women
-
批准号:8415364
-
项目类别:
-
资助金额:$39.04万
-
财政年份:2012
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
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批准号:7086895
-
项目类别:
-
资助金额:$184.0万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
-
批准号:8291265
-
项目类别:
-
资助金额:$61.19万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
-
批准号:6810109
-
项目类别:
-
资助金额:$153.25万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B Estradiol
-
批准号:7146778
-
项目类别:
-
资助金额:$28.53万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
-
批准号:7255399
-
项目类别:
-
资助金额:$197.83万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
-
批准号:6950692
-
项目类别:
-
资助金额:$169.74万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
-
批准号:7484954
-
项目类别:
-
资助金额:$199.25万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
-
批准号:7890314
-
项目类别:
-
资助金额:$172.36万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Biologic Response of Menopausal Women to 17B-Estradiol
-
批准号:8085742
-
项目类别:
-
资助金额:$217.32万
-
财政年份:2004
-
负责人:Howard Neil Hodis
-
依托单位:
Phytoestrogens and Progression of Atherosclerosis
-
批准号:6803575
-
项目类别:
-
资助金额:$110.09万
-
财政年份:2003
-
负责人:Howard Neil Hodis
-
依托单位:
Phytoestrogens and Progression of Atherosclerosis
-
批准号:7124984
-
项目类别:
-
资助金额:$189.68万
-
财政年份:2003
-
负责人:Howard Neil Hodis
-
依托单位:
Phytoestrogens and Progression of Atherosclerosis
-
批准号:7124955
-
项目类别:
-
资助金额:$4.87万
-
财政年份:2003
-
负责人:Howard Neil Hodis
-
依托单位: