Bruker Biospec 9.4T/40cm Bore MRI System

请求提供资金，以便能够购买用于动物研究的9.4特斯拉场强/ 40厘米直径孔磁共振成像扫描仪。11名研究人员作为主要用户和3名研究人员作为次要用户将共享该仪器，以加强他们的NIH/NSF资助的科学研究。该提案的目标是利用小动物模型在开发高场成像技术、BOLD对比度和神经元活动的机制研究中的潜力，特别是基因工程小鼠，作为癌症研究中的发现工具。沿着介绍了每个主要用户的项目说明，以及国家报告制度对每个项目的好处。该补助金的奖励将补充威斯康星州医学院（MCW）的资金用于购买仪器。MCW还将为拟议的网站建设提供资金，支持运营费用和人员。学院院长的机构承诺书附后。NCRR-SIG将由MCW生物物理研究所（BRI）与该学院的癌症中心和人类与分子遗传学中心联合管理。大口径将允许使用BRI MR物理团队已经设计和制造的高性能梯度。这些主动屏蔽、高强度、高转换率梯度将允许使用部分kspace梯度回忆回波平面成像（GR-EPI）采集图像的时间过程。由BRI开创的部分k空间EPI允许空间分辨率加倍，进一步促进了各种实验设计中空间和时间分辨率之间的权衡。四维数据集-空间和时间-可以进行后处理，以在时间和空间分辨率之间进行连续权衡。购买该成像系统还将为威斯康星州提供资源，因为它是唯一的超高场和大口径动物仪器。

Funds are requested to enable the purchase of 9.4 Tesla field strength / 40 cm diameter bore MRI scanner for animal research. Eleven investigators as major users and three investigators as minor users will share this instrument to enhance their NIH/NSF funded scientific research. The goal of the proposal is to capitalize on the potential of small animal models in the development of high field imaging technology, mechanistic studies of BOLD contrast and neuronal activity, and particularly genetically engineered mice, as discovery tools in cancer research. The project description of each major user is presented along with the benefits of the NCRR-SIG for each project. The award from this grant will be supplemented with Medical College of Wisconsin (MCW) funds for purchase of the instrument. MCW will also provide funds for the proposed site construction, support of operating expenses and personnel. A letter of institutional commitment from the dean of the college is attached. The NCRR-SIG will be administered by the MCW Biophysics Research Institute (BRI) in alliance with the college's Cancer Center and the Human and Molecular Genetics Center. The large bore will permit use of high performance gradients already designed and built by the BRI MR physics team. These actively shielded, high-strength, high slew-rate gradients will permit acquisition of a time course of images using partial kspace Gradient Recalled Echo Planar Imaging (GR-EPI). Partial k-space EPI, pioneered by the BRI, permits doubling of the spatial resolution, further facilitating the trade-off between spatial and temporal resolution in a variety of experimental designs. Four-dimensional data sets - space and time - can be post-processed for a continuous tradeoff between temporal and spatial resolution. The purchase of this imaging system will also provide a resource for the state of Wisconsin as the only super-high field and large bore animal instrument available.