Stable isotope tracing of nanomaterials in plants

植物中纳米材料的稳定同位素示踪

• 批准号: 1837754
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1837754
• 关键词: Stable; isotope; tracing; nanomaterials; plants

With the quick development of nanotechnology, there is an urgency for environmentally relevant exposure studies of engineered nanomaterials (ENMs) in plants that can be used for comprehensive risk assessment. Current studies on ENMs in plants, however, concentrate on effects at environmentally unrealistic concentrations (usually 100, 1,000 or sometimes 10,000 times higher than the predicted environmental concentrations) due to analytical limitations. Stable isotope tracing of NMs will allow to overcome these limitations and make the utilisation of environmentally relevant concentrations possible. It will also help distinguish the elemental background present in plants from the introduced labelled NMs. For this reason, this research project aims to (i.) study the behaviour and fate of ENMs in plants; (ii.) provide quantitative data on the uptake of NMs; (iii.) evaluate their bioavailability and potential phytotoxic effects at different plant growth stages at environmentally relevant concentrations by using labelled ENMs (including NMs such as Ag NMs and Zn NMs). After the completion of an exposure experiment, samples will be collected and analysed in the clean room and mass spectrometry facilities at Imperial College London. The project will aim to help policy makers assess the hazardous behaviour of ENMs in the environment.

随着纳米技术的快速发展，迫切需要对植物中工程纳米材料（ENM）的环境相关暴露进行研究，以进行全面的风险评估。然而，由于分析的局限性，目前对植物中的环境纳米物质的研究主要集中在对环境不切实际的浓度（通常是预测环境浓度的100倍、1，000倍或有时10，000倍）的影响上。纳米物质的稳定同位素示踪将允许克服这些限制，并使环境相关浓度的利用成为可能。它还将有助于区分植物中存在的元素背景与引入的标记NM。因此，本研究项目旨在（i.）研究ENM在植物中的行为和命运;（ii.）提供关于吸收国家药物的定量数据;通过使用标记的ENMs（包括NM，如Ag NM和Zn NM），在不同植物生长阶段以环境相关浓度评估其生物利用度和潜在的植物毒性效应。暴露实验完成后，将在伦敦帝国理工学院的洁净室和质谱设施中收集和分析样本。该项目旨在帮助政策制定者评估环境中化学物质的危险行为。