Modelling chronic toxicity in terrestrial mammals

模拟陆地哺乳动物的慢性毒性

• 批准号: 1843850
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1843850
• 关键词: Modelling; chronic; toxicity; terrestrial; mammals

Small mammals (e.g. field voles, wood mice) contribute to ecosystem services both in their own right and as prey for iconic predators such as birds of prey. In order to maintain food security while preserving ecosystem services it is important to understand the mechanisms of how different pesticide exposure patterns lead to ecotoxicological effects under field conditions. The aim of this project is to develop a toxicokinetic-toxicodynamic (TKTD) model to better understand, simulate and predict toxic effects of pesticides on wildlife, specifically effects on growth of small mammals. Existing laboratory toxicity studies with rats and mice will be used to develop and calibrate the model. The model aims to achieve two objectives: A. In-vitro to in-vivo toxicity extrapolation for effects on growth B. Assess the effects of different exposure patterns in the field for risk assessment.

小型哺乳动物（如田鼠、木鼠）以其自身的权利和作为猛禽等标志性捕食者的猎物，为生态系统服务做出了贡献。为了在保持生态系统服务的同时维持粮食安全，了解不同农药暴露模式在田间条件下如何导致生态毒理学效应的机制非常重要。该项目的目的是建立一个毒物动力学模型，以更好地了解、模拟和预测农药对野生动物的毒性作用，特别是对小型哺乳动物生长的影响。现有的大鼠和小鼠的实验室毒性研究将用于开发和校准该模型。该模型旨在实现两个目标：A.体外到体内的毒性外推对生长的影响B.评估现场不同暴露模式的影响，以进行风险评估。

项目成果

Common ground between growth models of rival theories: a useful illustration for beginners

竞争理论的增长模型之间的共同点：对初学者的有用说明

• 发表时间: 2019
• 期刊: Ecological Modelling
• 影响因子: 3.1
• 作者: T Martin