课题基金 / 基金详情

X RAY CRYSTALLOGRAPHIC STUDIES--COPPER CHAPERONE LYS7

X RAY CRYSTALLOGRAPHIC STUDIES--COPPER CHAPERONE LYS7
X射线晶体学研究--铜伴侣LYS7
批准号：
6385049
负责人：
AUDREY L LAMB
金额：
$4.02万
依托单位：
NORTHWESTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
未结题
起止时间：
1999-06-01 至
来源：
https://reporter.nih.gov/project-details/6385049
关键词：
X ray crystallography amine oxidase (copper) binding proteins bioimaging /biomedical imaging biological transport conformation copper crystallization electron spin resonance spectroscopy enzyme structure iron metabolism lysine metal metabolism metalloenzyme metalloproteins molecular chaperones protein binding protein protein interaction protein structure spectrometry structural biology superoxide dismutase yeasts

项目摘要

项目成果

AUDREY L LAMB的其他基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Superoxide dismutase catalyzes the disproportionation of superoxide to hydrogen peroxide and dioxygen. For activity, this exzyme requires one dimetallic Cu,Zn center per subunit. In yeast, the insertion of the copper into superoxide dismutase (Sod1) only occurs in the presence of the copper chaperone protein Lys7. The objective of this proposal is to solve the three dimensional structures of Lys7, with and without the metal ions, and Lys7 complexed with Sod1. In humans, Sod1 has been linked to familial amyotrophic lateral sclerosis (Lou Gehrig's Disease), and a detailed understanding of the mechanism of copper insertion should lead to the development of new therapies for this disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Novel and essential metallophores from multidrug resistant bacterial pathogens
  • 批准号：
    10211388
  • 项目类别：
  • 资助金额：
    $28.75万
  • 财政年份：
    2018
  • 负责人：
    AUDREY L LAMB
  • 依托单位：
    UNIVERSITY OF TEXAS SAN ANTONIO
Structure-function analyses of siderophore biosynthetic enzymes
  • 批准号：
    8431451
  • 项目类别：
  • 资助金额：
    $10.69万
  • 财政年份：
    2011
  • 负责人：
    AUDREY L LAMB
  • 依托单位：
    UNIVERSITY OF KANSAS LAWRENCE
Structure-function analyses of siderophore biosynthetic enzymes
  • 批准号：
    8231982
  • 项目类别：
  • 资助金额：
    $10.69万
  • 财政年份：
    2011
  • 负责人：
    AUDREY L LAMB
  • 依托单位：
    UNIVERSITY OF KANSAS LAWRENCE
Structure-function analyses of siderophore biosynthetic enzymes
  • 批准号：
    8086738
  • 项目类别：
  • 资助金额：
    $10.69万
  • 财政年份：
    2011
  • 负责人：
    AUDREY L LAMB
  • 依托单位：
    UNIVERSITY OF KANSAS LAWRENCE