Using mathematical modelling of the Langerhans cell tolerogenic gene regulatory network to identify key molecular regulators of the tolerogenic progra

利用朗格汉斯细胞耐受基因调控网络的数学模型来识别耐受程序的关键分子调节因子

• 批准号: 1856566
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1856566
• 关键词: Using; mathematical; modelling; Langerhans; cell

Skills Priority Alignment: Quantitative BiologyHypothesisLC tolerogenic ability is regulated by a unique gene regulatory network (GRN), which induces a distinct gene expression profile associated with the tolerogenic LC programme. Aims 1) Investigate cell-cell variation within LC populations.2) Dissect a unique gene expression profile associated with tolerance in LCs and identify the TFs essential for regulating LC tolerogenic function.3) Create a mathematical model of the LC tolerogenic GRN for quantitative in silico simulations that correctly predict the expression of tolerogenic output genes4) Identify the key molecular switches regulating tolerogenic responses and validate in vitro.

技能优先顺序：定量生物学假设LC 耐受性能力由独特的基因调控网络 (GRN) 调节，该网络诱导与耐受性 LC 程序相关的独特基因表达谱。目标 1) 研究 LC 群体内的细胞间变异。2) 剖析与 LC 耐受性相关的独特基因表达谱，并识别调节 LC 耐受性功能所必需的 TF。3) 创建 LC 耐受性 GRN 的数学模型，用于定量计算机模拟，正确预测耐受性输出基因的表达 4) 识别调节耐受性反应的关键分子开关并验证 体外。

项目成果

Langerhans Cells-Programmed by the Epidermis.

• DOI: 10.3389/fimmu.2017.01676
• 发表时间: 2017
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Clayton K;Vallejo AF;Davies J;Sirvent S;Polak ME
• 通讯作者: Polak ME